Integrated optical Mach-Zehnder biosensor

被引：218
|
作者：
Luff, BJ [1 ]
Wilkinson, JS
Piehler, J
Hollenbach, U
Ingenhoff, J
Fabricius, N
机构：
[1] Univ Southampton, Optoelect Res Ctr, Southampton SO17 1BJ, Hants, England
[2] Univ Tubingen, Inst Phys & Theoret Chem, D-7400 Tubingen, Germany
[3] IOT Entwicklungsgesell Integrierte Opt Technol Gm, D-6833 Waghausel Kirrlach, Germany
来源：
JOURNAL OF LIGHTWAVE TECHNOLOGY | 1998年 / 16卷 / 04期
基金：
英国工程与自然科学研究理事会;
关键词：
biomedical transducers; integrated optics; interferometry; waveguides; waveguide couplers;
D O I：
10.1109/50.664067
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
We present measurements on biomolecular surface multilayers using an integrated optical sensor based on the Mach-Zehnder interferometer (MZI). The sensor design is unique in that it incorporates a three-waveguide coupler structure at the interferometer output which gives advantages in terms of signal referencing and in establishing and maintaining a sensitive operating point. The sensor performance is characterized with respect to bulk superstrate index and by the formation of multiple protein adlayers using a biotin-avidin-based biochemical system. The detection limit for protein loading is estimated as 5 pg/mm(2).
引用
收藏
页码：583 / 592
页数：10
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