Integrated optical Mach-Zehnder biosensor

被引：218

作者：

Luff, BJ ^{[1
]}

Wilkinson, JS

Piehler, J

Hollenbach, U

Ingenhoff, J

Fabricius, N

机构：

[1] Univ Southampton, Optoelect Res Ctr, Southampton SO17 1BJ, Hants, England

[2] Univ Tubingen, Inst Phys & Theoret Chem, D-7400 Tubingen, Germany

[3] IOT Entwicklungsgesell Integrierte Opt Technol Gm, D-6833 Waghausel Kirrlach, Germany

来源：

JOURNAL OF LIGHTWAVE TECHNOLOGY | 1998年 / 16卷 / 04期

基金：

英国工程与自然科学研究理事会;

关键词：

biomedical transducers; integrated optics; interferometry; waveguides; waveguide couplers;

D O I：

10.1109/50.664067

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

We present measurements on biomolecular surface multilayers using an integrated optical sensor based on the Mach-Zehnder interferometer (MZI). The sensor design is unique in that it incorporates a three-waveguide coupler structure at the interferometer output which gives advantages in terms of signal referencing and in establishing and maintaining a sensitive operating point. The sensor performance is characterized with respect to bulk superstrate index and by the formation of multiple protein adlayers using a biotin-avidin-based biochemical system. The detection limit for protein loading is estimated as 5 pg/mm(2).

引用

页码：583 / 592

页数：10

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