Synthesis of 5-substituted analogues of huperzine A

被引：10

作者：

Zhou, GC ^{[1
]}

Zhu, DY ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 200031, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 18期

关键词：

D O I：

10.1016/S0960-894X(00)00408-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three 5-isosteres of huperzine A (2-4) were first synthesized. The key intermediate 10 was prepared by the reaction of acid 13 with LTA. The compounds 2 and 3 had 50% inhibition by 35 and 47 mu M, respectively, which still retained anti-acetylcholinesterase activity. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2055 / 2057

页数：3

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