Successful Treatment of Resistant Antiglomerular Basement Membrane Antibody Positivity with Mycophenolic Acid

被引:17
作者
Kiykim, Ahmet Alper [1 ]
Horoz, Mehmet [1 ]
Gok, Ebru [1 ]
机构
[1] Mersin Univ, Sch Med, Div Nephrol, Dept Internal Med, Mersin, Turkey
关键词
anti-GBM-antibody; RPGN; mycophenolic acid; hemodialysis; GLOMERULONEPHRITIS; NEPHRITIS;
D O I
10.2169/internalmedicine.49.2321
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Anti-glomerular basement membrane (GBM) antibody disease may progress to end-stage renal failure, requiring either dialysis or renal transplantation. In patients with end-stage renal disease (ESRD) due to anti-GBM-ab disease, the recurrence rate after transplantation is as high as 50% (2) and delaying renal transplantation until circulating anti-GBM antibody levels have been undetectable for at least 12 months reduces the recurrence rate to 5-15%. We report a case of ESRD due to renal limited anti-GBM disease with circulating anti-GBM-ab resistant to standard treatment approach who achieved undetectable anti-GBM-ab with mycophenolic acid.
引用
收藏
页码:577 / 580
页数:4
相关论文
共 8 条
[1]   RECURRENCE OF ANTI-GLOMERULAR BASEMENT-MEMBRANE ANTIBODY MEDIATED GLOMERULONEPHRITIS IN AN ISOGRAFT [J].
ALMKUIST, RD ;
BUCKALEW, VM ;
HIRSZEL, P ;
MAHER, JF ;
JAMES, PM ;
WILSON, CB .
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1981, 18 (01) :54-60
[2]   Recurrent glomerulonephritis after kidney transplantation [J].
Choy, B. Y. ;
Chan, T. M. ;
Lai, K. N. .
AMERICAN JOURNAL OF TRANSPLANTATION, 2006, 6 (11) :2535-2542
[3]   Characteristics and outcome of anti-glomerular basement membrane disease: A single-center experience [J].
Daly, C ;
Conlon, PJ ;
Medwar, W ;
Walshe, JJ .
RENAL FAILURE, 1996, 18 (01) :105-112
[4]  
*EBPG EXP GROUP HA, 2002, NEPHROL DIAL TRAN S7, V17, P16
[5]   Long-term outcome of anti-glomerular basement membrane antibody disease treated with plasma exchange and immunosuppression [J].
Levy, JB ;
Turner, AN ;
Rees, AJ ;
Pusey, CD .
ANNALS OF INTERNAL MEDICINE, 2001, 134 (11) :1033-1042
[6]  
Nieto E, 2002, J AM SOC NEPHROL, V13, DOI 10.1681/ASN.V134937
[7]  
PETERS DK, 1982, TRANSPLANT P, V14, P513
[8]  
PUSEY CD, 1990, CLIN EXP IMMUNOL, V81, P76