Rapid electronic prediction of gene expression regulation in bacterial cells

被引：1
作者：
Alam, S. [1 ]
Lai, E. M-K. [1 ]
Young, J. [2 ]
Hasan, S. M. R. [1 ]
机构：
[1] Massey Univ, Sch Engn & Adv Technol, Auckland, New Zealand
[2] Massey Univ, Inst Nat & Math Sci, Auckland, New Zealand
来源：
ELECTRONICS LETTERS | 2014年 / 50卷 / 22期
关键词：
14;
D O I：
10.1049/el.2014.2144
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
A cytomorphic circuit that can mimic gene expression regulation mechanisms is presented. It is shown that this circuit can efficiently predict the cellular response of the bacterium Escherichia coli in real time. The simulation outputs of the circuit are compared with biological experimental results. The significant similarity between these results shows that the circuit can be used to predict cellular malfunctioning within microseconds.
引用
收藏
页码：1566 / 1567
页数：2
相关论文
共 14 条
  • [1] Integrated Circuit Modeling of Biocellular Post-Transcription Gene Mechanisms Regulated by MicroRNA and Proteasome
    Alam, Sadia
    Hasan, S. M. Rezaul
    [J]. IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS I-REGULAR PAPERS, 2013, 60 (09) : 2298 - 2310
  • [2] [Anonymous], 2010, GEN GEN EXPR EXP GUI, P29
  • [3] NUTRITIONAL REQUIREMENTS FOR HYDROGENASE PRODUCTION BY ESCHERICHIA-COLI
    BILLEN, D
    LICHSTEIN, HC
    [J]. JOURNAL OF BACTERIOLOGY, 1950, 60 (03) : 311 - 314
  • [4] Boyer R., 2012, Biochemistry Laboratory: Modern Theory and Techniques, V2
  • [5] Campbell N.A., 2005, Biology
  • [6] Chen DC, 2004, I C CONT AUTOMAT ROB, P1023
  • [7] da Silva N., 2013, Microbiological examination methods of food and water: a laboratory manual, Second edition
  • [8] Doonan C., 2010, P 31 W C ASS BIOL LA, P95
  • [9] Dykstra M.J., 1993, MANUAL APPL TECHNIQU, V1
  • [10] Scanning assay of β-galactosidase activity
    Li, W.
    Zhao, X.
    Zou, S.
    Ma, Y.
    Zhang, K.
    Zhang, M.
    [J]. APPLIED BIOCHEMISTRY AND MICROBIOLOGY, 2012, 48 (06) : 603 - 607
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