Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine

被引:212
作者
Dhyani, Praveen [1 ]
Quispe, Cristina [2 ]
Sharma, Eshita [3 ]
Bahukhandi, Amit [4 ]
Sati, Priyanka [5 ]
Attri, Dharam Chand [4 ]
Szopa, Agnieszka [6 ]
Sharifi-Rad, Javad [7 ]
Docea, Anca Oana [8 ]
Mardare, Ileana [9 ]
Calina, Daniela [10 ]
Cho, William C. [11 ]
机构
[1] Kumaun Univ, Dept Biotechnol, Bhimtal 263136, Uttarakhand, India
[2] Univ Arturo Prat, Fac Ciencias Salud, Avda Arturo Prat 2120, Iquique 1110939, Chile
[3] Guru Nanak Dev Univ, Dept Mol Biol & Biochem, Amritsar 143005, Punjab, India
[4] GB Pant Natl Inst Himalayan Environm, Almora 263643, Uttarakhand, India
[5] Graph Era Univ, Dehra Dun 248001, Uttarakhand, India
[6] Jagiellonian Univ, Chair & Dept Pharmaceut Bot, Med Coll, Medyczna 9, PL-30688 Krakow, Poland
[7] Univ Azuay, Fac Med, Cuenca, Ecuador
[8] Univ Med & Pharm Craiova, Dept Toxicol, Craiova 200349, Romania
[9] Carol Davila Univ Med & Pharm Bucharest, Dept Publ Hlth & Management, Bucharest 050463, Romania
[10] Univ Med & Pharm Craiova, Dept Clin Pharm, Craiova 200349, Romania
[11] Queen Elizabeth Hosp, Dept Clin Oncol, Kowloon, Hong Kong, Peoples R China
基金
英国科研创新办公室;
关键词
Alkaloids; Vinca; Catharanthus; Colchicum; Anticancer; Microtubule-targeting agents; Antimitotic; Apoptosis; CELL-CYCLE ARREST; BREAST-CANCER; MICROTUBULE DYNAMICS; LEAF EXTRACT; AGENTS; CHEMOTHERAPY; MECHANISMS; APOPTOSIS; L; PHARMACOKINETICS;
D O I
10.1186/s12935-022-02624-9
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Cancer, one of the leading illnesses, accounts for about 10 million deaths worldwide. The treatment of cancer includes surgery, chemotherapy, radiation therapy, and drug therapy, along with others, which not only put a tremendous economic effect on patients but also develop drug resistance in patients with time. A significant number of cancer cases can be prevented/treated by implementing evidence-based preventive strategies. Plant-based drugs have evolved as promising preventive chemo options both in developing and developed nations. The secondary plant metabolites such as alkaloids have proven efficacy and acceptability for cancer treatment. Apropos, this review deals with a spectrum of promising alkaloids such as colchicine, vinblastine, vincristine, vindesine, vinorelbine, and vincamine within different domains of comprehensive information on these molecules such as their medical applications (contemporary/traditional), mechanism of antitumor action, and potential scale-up biotechnological studies on an in-vitro scale. The comprehensive information provided in the review will be a valuable resource to develop an effective, affordable, and cost effective cancer management program using these alkaloids.
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页数:20
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