Deformed wing virus

被引：408
作者：
de Miranda, Joachim R. [2 ]
Genersch, Elke [1 ]
机构：
[1] Inst Bee Res, Dept Mol Microbiol & Bee Dis, D-16540 Hohen Neuendorf, Germany
[2] Swedish Univ Agr Sci, Dept Ecol, S-75007 Uppsala, Sweden
来源：
JOURNAL OF INVERTEBRATE PATHOLOGY | 2010年 / 103卷
关键词：
Deformed wing virus (DWV); Genetics; Pathology; Transmission; Virulence; Biological vector; PICORNA-LIKE-VIRUS; HONEYBEES APIS-MELLIFERA; BEE PARALYSIS VIRUS; MOUTH-DISEASE VIRUS; STRAND RNA VIRUSES; VERTICAL-TRANSMISSION; VARROA-JACOBSONI; SACBROOD VIRUS; VIRAL LOAD; STRUCTURAL MOTIFS;
D O I：
10.1016/j.jip.2009.06.012
中图分类号：
Q95 [动物学];
学科分类号：
071002 ;
摘要：
Deformed wing virus (DWV; Iflaviridae) is one of many viruses infecting honeybees and one of the most heavily investigated due to its close association with honeybee colony collapse induced by Varroa destructor. In the absence of V. destructor DWV infection does not result in visible symptoms or any apparent negative impact on host fitness. However, for reasons that are still not fully understood, the transmission of DWV by V. destructor to the developing pupae causes clinical symptoms, including pupal death and adult bees emerging with deformed wings, a bloated, shortened abdomen and discolouration. These bees are not viable and die soon after emergence. In this review we will summarize the historical and recent data on DWV and its relatives, covering the genetics, pathobiology, and transmission of this important viral honeybee pathogen, and discuss these within the wider theoretical concepts relating to the genetic variability and population structure of RNA viruses, the evolution of virulence and the development of disease symptoms. (C) 2009 Elsevier Inc. All rights reserved
引用
收藏
页码：S48 / S61
页数：14
相关论文
共 174 条
[51]   VIRAL QUASI-SPECIES [J].
EIGEN, M .
SCIENTIFIC AMERICAN, 1993, 269 (01) :42-49
[52]   SELFORGANIZATION OF MATTER AND EVOLUTION OF BIOLOGICAL MACROMOLECULES [J].
EIGEN, M .
NATURWISSENSCHAFTEN, 1971, 58 (10) :465-+
[53]   Error catastrophe and antiviral strategy [J].
Eigen, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (21) :13374-13376
[54]   Virus evolution:: Insights from an experimental approach [J].
Elena, Santiago F. ;
Sanjuan, Rafael .
ANNUAL REVIEW OF ECOLOGY EVOLUTION AND SYSTEMATICS, 2007, 38 :27-52
[55]   The worldwide health status of honey bees [J].
Ellis, JD ;
Munn, PA .
BEE WORLD, 2005, 86 (04) :88-101
[56]   HOST-PARASITE RELATIONS, VECTORS, AND THE EVOLUTION OF DISEASE SEVERITY [J].
EWALD, PW .
ANNUAL REVIEW OF ECOLOGY AND SYSTEMATICS, 1983, 14 :465-485
[57]  
Eyer M, 2009, APIDOLOGIE, V40, P419, DOI 10.1051/apido:2008051
[58]   Relevance of RNA structure for the activity of picornavirus IRES elements [J].
Fernandez-Miragall, Olga ;
Lopez de Quinto, Sonia ;
Martinez-Salas, Encarnacion .
VIRUS RESEARCH, 2009, 139 (02) :172-182
[59]   Localization of deformed wing virus infection in queen and drone Apis mellifera L [J].
Fievet, Julie ;
Tentcheva, Diana ;
Gauthier, Laurent ;
de Miranda, Joachim ;
Cousserans, Francois ;
Colin, Marc Edouard ;
Bergoin, Max .
VIROLOGY JOURNAL, 2006, 3 (1)
[60]  
FLINT SJ, 2004, PRINCIPLES VIROLOGY, pCH7
12345678910