Rapid effects of neurotrophic factors on calcium homeostasis in rat visceral afferent neurons

被引：7

作者：

Lamb, K ^{[1
]}

Bielefeldt, K ^{[1
]}

机构：

[1] Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA

来源：

NEUROSCIENCE LETTERS | 2003年 / 336卷 / 01期

关键词：

nodose ganglion; calcium homeostasis; nerve growth factor; glial derived neurotrophic factor; brain derived neurotrophic factor;

D O I：

10.1016/S0304-3940(02)01223-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neurotrophic factors maintain and modulate neuron function in adults. We tested the hypothesis that neurotrophic factors rapidly alter intracellular calcium concentrations, thereby affecting neuron excitability. The majority of rat nodose neurons express TrkA, TrkB and TrkC receptor after 1 day in culture. Addition of nerve growth factor, brain derived neurotrophic factor or glial derived neurotrophic factor increased cytosolic calcium in about one third of the neurons within less than 10 min. This increase was due to calcium release from intracellular stores and could be blocked by the tyrosine kinase inhibitor K252a. The rapid effect of neurotrophic factors suggests a role of these molecules in the early response after inflammation as potential mediators for sensitization of afferent neurons. (C) 2002 Published by Elsevier Science Ireland Ltd.

引用

页码：9 / 12

页数：4

共 21 条

[1] Tacrolimus (FK506) modulates calcium release and contractility of intestinal smooth muscle [J].