Introduction to special issue: Challenges and opportunities for regeneration in the peripheral nervous system

被引：76

作者：

Hoeke, Ahmet ^{[1
,2
]}

Brushart, Thomas ^{[1
,3
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Orthoped, Baltimore, MD USA

来源：

EXPERIMENTAL NEUROLOGY | 2010年 / 223卷 / 01期

关键词：

Peripheral nerve regeneration; Conditioning lesion; Preferential motor reinnervation; Chronic denervation; Schwann cell; SCHWANN-CELL DENERVATION; POOR FUNCTIONAL RECOVERY; RAT SCIATIC-NERVE; AXONAL REGENERATION; CONDITIONING LESION; MOTOR AXONS; CONTRIBUTING FACTORS; PROTEIN-TRANSPORT; RE-INNERVATION; MUSCLE-FIBERS;

D O I：

10.1016/j.expneurol.2009.12.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Regeneration in the peripheral nervous system offers unique opportunities and challenges to medicine. Compared to the central nervous system, peripheral axons can and do regenerate resulting in functional recovery, especially if the distance to target is short as in distal limb injuries. However, this regenerative capacity is often incomplete and functional recovery with proximal lesions is limited. Furthermore, regeneration of axons to the appropriate targets remains a challenge with inappropriate reinnervation being an impediment to full recovery. The reviews and selected original research papers in this Special Issue will address some of these challenges and highlight new opportunities for development of effective therapies for nerve regeneration. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：1 / 4

页数：4

共 56 条

[1] NEURAL PLASTICITY .3. RESPONSES TO LESIONS IN THE PERIPHERAL NERVOUS-SYSTEM [J].