Understanding Latent Tuberculosis: A Moving Target

被引：341

作者：

Lin, Philana Ling ^{[2
]}

Flynn, JoAnne L. ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Microbiol & Mol Genet, Sch Med, Pittsburgh, PA 15261 USA

[2] Univ Pittsburgh, Dept Pediat, Childrens Hosp Pittsburgh, Med Ctr, Pittsburgh, PA 15224 USA

来源：

JOURNAL OF IMMUNOLOGY | 2010年 / 185卷 / 01期

基金：

美国国家卫生研究院;

关键词：

TUMOR-NECROSIS-FACTOR; HUMAN-IMMUNODEFICIENCY-VIRUS; NITRIC-OXIDE SYNTHASE; CD8(+) T-CELLS; MYCOBACTERIUM-TUBERCULOSIS; PULMONARY TUBERCULOSIS; ACTIVE TUBERCULOSIS; ANTIRETROVIRAL THERAPY; DISEASE PROGRESSION; IMMUNE-RESPONSES;

D O I：

10.4049/jimmunol.0903856

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tuberculosis (TB) remains a threat to the health of people worldwide. Infection with Mycobacterium tuberculosis can result in active TB or, more commonly, latent infection. Latently infected persons, of which there are estimated to be similar to 2 billion in the world, represent an enormous reservoir of potential reactivation TB, which can spread to other people. The immunology of TB is complex and multifaceted. Identifying the immune mechanisms that lead to control of initial infection and prevent reactivation of latent infection is crucial to combating this disease. The Journal of Immunology, 2010, 185: 15-22.

引用

页码：15 / 22

页数：8

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