Regioselective control of electrophilic aromatic substitution reactions

被引：67

作者：

Smith, K ^{[1
]}

El-Hiti, GA ^{[1
]}

机构：

[1] Univ Coll Swansea, Ctr Clean Chem, Dept Chem, Swansea SA2 8PP, W Glam, Wales

来源：

CURRENT ORGANIC SYNTHESIS | 2004年 / 1卷 / 03期

关键词：

regioisomers; zeolites; electrophilic aromatic substitution reactions; directed lithiation; shape selectivity; heterocycles;

D O I：

10.2174/1570179043366747

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

para-Regioselective electrophilic aromatic substitution reactions, for example nitration, alkylation, acylation, sulfonylation and halogenation, can be achieved by carrying out reactions over solid catalysts such as zeolites, under modest conditions via shape-selectivity. By contrast, organolithium reagents can play an important role when ortho-products are desirable. ortho-Lithiation has been applied for the synthesis of more complex substituted heterocycles that are difficult to prepare by other means.

引用

页码：253 / 274

页数：22

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