The Proteome in Balance

被引:41
作者
Hutt, Darren [1 ]
Balch, William E. [1 ,2 ,3 ]
机构
[1] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Dept Physiol Chem, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
[3] Scripps Res Inst, Inst Childhood & Neglected Dis, La Jolla, CA 92037 USA
关键词
CYSTIC-FIBROSIS; CHAPERONE; PROTEOSTASIS; DISEASE; CFTR;
D O I
10.1126/science.1194160
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:766 / 767
页数:2
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  • [1] Adapting proteostasis for disease intervention
    Balch, William E.
    Morimoto, Richard I.
    Dillin, Andrew
    Kelly, Jeffery W.
    [J]. SCIENCE, 2008, 319 (5865) : 916 - 919
  • [2] The role of molecular chaperones in human misfolding diseases
    Broadley, Sarah A.
    Hartl, F. Ulrich
    [J]. FEBS LETTERS, 2009, 583 (16): : 2647 - 2653
  • [3] Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance
    Geller, Ron
    Vignuzzi, Marco
    Andino, Raul
    Frydman, Judith
    [J]. GENES & DEVELOPMENT, 2007, 21 (02) : 195 - 205
  • [4] Converging concepts of protein folding in vitro and in vivo
    Hartl, F. Ulrich
    Hayer-Hartl, Manajit
    [J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2009, 16 (06) : 574 - 581
  • [5] The proteostasis boundary in misfolding diseases of membrane traffic
    Hutt, Darren M.
    Powers, Evan T.
    Balch, William E.
    [J]. FEBS LETTERS, 2009, 583 (16) : 2639 - 2646
  • [6] Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging
    Morimoto, Richard I.
    [J]. GENES & DEVELOPMENT, 2008, 22 (11) : 1427 - 1438
  • [7] Protein Homeostasis and Aging: Taking Care of Proteins From the Cradle to the Grave
    Morimoto, Richard I.
    Cuervo, Ana M.
    [J]. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2009, 64 (02): : 167 - 170
  • [8] Peripheral Protein Quality Control Removes Unfolded CFTR from the Plasma Membrane
    Okiyoneda, Tsukasa
    Barriere, Herve
    Bagdany, Miklos
    Rabeh, Wael M.
    Du, Kai
    Hoehfeld, Joerg
    Young, Jason C.
    Lukacs, Gergely L.
    [J]. SCIENCE, 2010, 329 (5993) : 805 - 810
  • [9] Signals of youth: endocrine regulation of aging in Caenorhabditis elegans
    Panowski, Siler H.
    Dillin, Andrew
    [J]. TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2009, 20 (06) : 259 - 264
  • [10] Biological and Chemical Approaches to Diseases of Proteostasis Deficiency
    Powers, Evan T.
    Morimoto, Richard I.
    Dillin, Andrew
    Kelly, Jeffery W.
    Balch, William E.
    [J]. ANNUAL REVIEW OF BIOCHEMISTRY, 2009, 78 : 959 - 991