Hemorphins Act as Homeostatic Agents in Response to Endotoxin-Induced Stress

被引：12

作者：

Barkhudaryan, Nina ^{[1
]}

Zakaryan, Hermine ^{[1
]}

Sarukhanyan, Flora ^{[1
]}

Gabrielyan, Anna ^{[1
]}

Dosch, Dominik ^{[2
]}

Kellermann, Josef ^{[2
]}

Lottspeich, Friedrich ^{[2
]}

机构：

[1] Natl Acad Sci, H Buniatian Inst Biochem, Yerevan 0014, Armenia

[2] Max Planck Inst Biochem, D-82152 Martinsried, Germany

来源：

NEUROCHEMICAL RESEARCH | 2010年 / 35卷 / 06期

关键词：

Hemorphin; Endotoxin-induced stress; Calcineurin; Corticosterone; TNF alpha; Immunophilin; CORONARO-CONSTRICTORY PEPTIDE; NF-KAPPA-B; PROTEIN PHOSPHATASE; OPIOID-PEPTIDES; IN-VIVO; PERITONEAL-MACROPHAGES; BETA-CHAIN; HPA AXIS; HEMOGLOBIN; RECEPTOR;

D O I：

10.1007/s11064-009-0097-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of synthetic LVV-hemorphin-7 and hemorphin-7 on hypothalamo-pituitary-adrenocortical axis activity in response to endotoxin-induced stress was studied. The intraperitoneal (ip) endotoxin (lipopolysaccaride, LPS) (0.5 mg/kg) administration in combination with hemorphin (1 mg/kg) induce significant decrease in plasma corticosterone and modest decrease in plasma levels of tumor necrosis factor-alpha (TNF alpha) in compare with elevated levels of both corticosterone and TNF alpha in plasma of rats received LPS administration alone. Increased activity of calcineurin in both plasma and brain of rats received ip administration of LPS, was recovered under LPS + hemorphin treatment. In two independent proteome analysis, using 2-dimensional fluorescence difference gel electrophoresis and the isotope coded protein label technology, peptidyl-prolyl cis-trans-isomerase A (cyclophilin A) was identified as regulated by hemorphins protein in mouse brain. A therapeutic potential of hemorphins and mechanisms of their homeostatic action in response to endotoxin-induced stress are discussed.

引用

页码：925 / 933

页数：9

共 68 条

[61] IDENTIFICATION OF CYCLOPHILIN AS A PROINFLAMMATORY SECRETORY PRODUCT OF LIPOPOLYSACCHARIDE-ACTIVATED MACROPHAGES [J].

SHERRY, B ;

YARLETT, N ;

STRUPP, A ;

CERAMI, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (08) :3511-3515

[62] Lipopolysaccharide activates calcineurin in ventricular myocytes [J].

Suzuki, Jun ;

Bayna, Evelyn ;

Li, Hat Ling ;

Dalle Molle, Erminia ;

Lew, Wilbur Y. W. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 49 (04) :491-499

[63] Nuclear Ca2+/calmodulin translocation activated by μ-opioid (OP3) receptor [J].

Wang, DX ;

Tolbert, LM ;

Carlson, KW ;

Sadée, W .

JOURNAL OF NEUROCHEMISTRY, 2000, 74 (04) :1418-1425

[64] Calcineurin regulation of synaptic function: From ion channels to transmitter release and gene transcription [J].

Yakel, JL .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1997, 18 (04) :124-134

[65] Inhibitory effects of spinorphin, a novel endogenous regulator, on chemotaxis, O-2(-) generation, and exocytosis by N-formylmethionyl-leucyl-phenylalanine (FMLP)-stimulated neutrophils [J].

Yamamoto, Y ;

Kanazawa, T ;

Shimamura, M ;

Ueki, M ;

Hazato, T .

BIOCHEMICAL PHARMACOLOGY, 1997, 54 (06) :695-701

[66] LVV- and VV-hemorphins: comparative levels in rat tissues [J].

Yatskin, ON ;

Philippova, MM ;

Blishchenko, EY ;

Karelin, AA ;

Ivanov, VT .

FEBS LETTERS, 1998, 428 (03) :286-290

[67] Impairment of T cell interactions with antigen-presenting cells by immunosuppressive drugs reveals involvement of calcineurin and NF-κB in immunological synapse formation [J].

Zeyda, Maximilian ;

Geyeregger, Rene ;

Poglitsch, Marko ;

Weichhart, Thomas ;

Zlabinger, Gerhard J. ;

Koyasu, Shigeo ;

Hoerl, Walter H. ;

Stulnig, Thomas M. ;

Watschinger, Bruno ;

Saemann, Marcus D. .

JOURNAL OF LEUKOCYTE BIOLOGY, 2007, 81 (01) :319-327

[68]

Zhao Q, 1997, BIOPOLYMERS, V43, P75

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