Silver(i)-catalyzed tandem reaction of enynones and 4-alkynyl isoxazoles: regioselective synthesis of highly functionalized 4H-furan[3,4-c]pyrroles

被引：5

作者：

Peng, Haiyun ^{[1
,2
]}

Zhang, Yangyi ^{[1
,2
]}

Deng, Guisheng ^{[1
,2
]}

Deng, Hongmei ^{[3
]}

机构：

[1] Hunan Normal Univ, Minist Educ China, Key Lab Chem Biol & Tradit Chinese Med Res, Changsha 410081, Peoples R China

[2] Hunan Normal Univ, Key Lab Assembly & Applicat Organ Funct Mol Hunan, Changsha 410081, Peoples R China

[3] Guangzhou Univ, Sch Environm Sci & Engn, Minist Educ, Key Lab Water Safety & Protect Pearl River Delta, Guangzhou 510006, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2021年 / 8卷 / 18期

基金：

中国国家自然科学基金;

关键词：

STRUCTURE-BASED DESIGN; ENE-YNE-KETONES; C-H ACTIVATION; 1,3-DIPOLAR CYCLOADDITION; BACE1; INHIBITORS; LIGANDS; FURANS; 2-(1-ALKYNYL)-2-ALKEN-1-ONES; ANNULATION; DISCOVERY;

D O I：

10.1039/d1qo00510c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This work reports a silver(i)-catalyzed tandem reaction of enynones with 4-alkynyl isoxazoles. The reaction occurred via yne-enones bearing an imine group as a key intermediate. The subsequent tandem cyclization of the intermediate provided access to highly functionalized 4H-furo[3,4-c]pyrrole derivatives. No 6 pi electrocyclic reaction of the key intermediate was observed.

引用

页码：5008 / 5012

页数：5

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