Spirometry follow-up in young children with hemato-oncologic diseases

被引:0
|
作者
Efrati, Ori [1 ]
Toren, Amos
Duskin, Hadar
Goldstein, Gal [2 ]
Jacobson, Jeffrey M. [3 ]
Churi, Chaim [2 ]
Vilozni, Daphna
机构
[1] Tel Aviv Univ, Sackler Sch Med, Sheba Med Ctr, Pediat Pulm Unit,Edmond & Lili Safra Childrens Ho, IL-52621 Ramat Gan, Israel
[2] Tel Aviv Univ, Sackler Sch Med, Edmond & Lili Safra Childrens Hosp, Sheba Med Ctr,Hematooncol Dept, IL-52621 Ramat Gan, Israel
[3] Tel Aviv Univ, Sackler Sch Med, Edmond & Lili Safra Childrens Hosp, Diagnost Imaging Dept,Sheba Med Ctr, IL-52621 Ramat Gan, Israel
来源
MEDICAL SCIENCE MONITOR | 2010年 / 16卷 / 03期
关键词
lung function tests; young children; acute lymphoblastic leukemia; Hodgkin lymphoma; stem cell transplantation; BONE-MARROW-TRANSPLANTATION; PULMONARY-FUNCTION; LUNG-FUNCTION; FUNCTION ABNORMALITIES; RESPIRATORY-FUNCTION; CHILDHOOD; COMPLICATIONS; SURVIVORS;
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Background: Treatment of hemato-oncologic patients is often associated with severe pulmonary complications. Pulmonary function is routinely evaluated in older children, whereas in young patients, forced spirometry measurements are infrequently performed. Aim: To assess severity of airway disease using forced spirometry measured prior to and after treatment (over 3 years) in hemato-oncologic children aged 3-7 years in comparison to a healthy population. Material/Methods: 42-children (18-males; age 3-7 years old) with hemato-oncologic illnesses participated in the study. Spirometry was performed before the definitive treatment and up-to 3-years thereafter. Values were compared to those of healthy children of corresponding age. Results: Most children (n=38) showed only minor long term airflow impairment (z-scores of FEV1 at last measurement was -0.00 to -0.45 SD). Prior to definitive treatment eight children presented severe airflow limitation (z-score=-1.35 +/- 0.72; -1.61 +/- 0.66 and -2.49 +/- 0.34 for FEV1, FEV0.5; and FEF25-75 respectively). Four of eight children resumed normal pulmonary function; the spirometry values of the other four children further deteriorated, in association with GVHD and development of bronchiolitis obliterans. Conclusions: Our study suggests that it is important to follow spirometry in young children with hemato-oncologic diseases in order to detect these patients, whose condition may have prognostic implications for their treatment.
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收藏
页码:MT28 / MT33
页数:6
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