HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1

被引：260

作者：

Schoofs, Till ^{[1
]}

Klein, Florian ^{[1
,2
,3
]}

Braunschweig, Malte ^{[1
,4
]}

Kreider, Edward F. ^{[5
,6
]}

Feldmann, Anna ^{[7
]}

Nogueira, Lilian ^{[1
]}

Oliveira, Thiago ^{[1
]}

Lorenzi, Julio C. C. ^{[1
]}

Parrish, Erica H. ^{[5
,6
]}

Learn, Gerald H. ^{[5
,6
]}

West, Anthony P., Jr. ^{[8
]}

Bjorkman, Pamela J. ^{[8
]}

Schlesinger, Sarah J. ^{[1
]}

Seaman, Michael S. ^{[9
]}

Czartoski, Julie ^{[10
]}

McElrath, M. Juliana ^{[10
]}

Pfeifer, Nico ^{[7
]}

Hahn, Beatrice H. ^{[5
,6
]}

Caskey, Marina ^{[1
]}

Nussenzweig, Michel C. ^{[1
,11
]}

机构：

[1] Rockefeller Univ, Lab Mol Immunol, New York, NY 10065 USA

[2] Univ Cologne, Ctr Mol Med Cologne, Lab Expt Immunol, D-50931 Cologne, Germany

[3] Univ Hosp Cologne, Ctr Integrated Oncol Cologne Bonn, Dept Internal Med, D-50937 Cologne, Germany

[4] Univ Freiburg, Hugstetter Str 55, D-79106 Freiburg, Germany

[5] Univ Penn, Dept Med, Perelman Sch Med, Philadelphia, PA 19104 USA

[6] Univ Penn, Dept Microbiol, Perelman Sch Med, Philadelphia, PA 19104 USA

[7] Max Planck Inst Informat, Dept Computat Biol & Appl Algorithm, Campus E14, D-66123 Saarbrucken, Germany

[8] CALTECH, Dept Biol, Pasadena, CA 91125 USA

[9] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02215 USA

[10] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98109 USA

[11] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10065 USA

来源：

SCIENCE | 2016年 / 352卷 / 6288期

基金：

欧洲研究理事会;

关键词：

BROADLY NEUTRALIZING ANTIBODIES; GENETIC SEQUENCE DIVERSITY; 2-SAMPLE TESTS; HUMANIZED MICE; CD4; BINDING; VACCINE; MACAQUES; VIREMIA; IMMUNOTHERAPY; POPULATIONS;

D O I：

10.1126/science.aaf0972

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

3BNC117 is a broad and potent neutralizing antibody to HIV-1 that targets the CD4 binding site on the viral envelope spike. When administered passively, this antibody can prevent infection in animal models and suppress viremia in HIV-1-infected individuals. Here we report that HIV-1 immunotherapy with a single injection of 3BNC117 affects host antibody responses in viremic individuals. In comparison to untreated controls that showed little change in their neutralizing activity over a 6-month period, 3BNC117 infusion significantly improved neutralizing responses to heterologous tier 2 viruses in nearly all study participants. We conclude that 3BNC117-mediated immunotherapy enhances host humoral immunity to HIV-1.

引用

页码：997 / 1001

页数：5

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