The Roles of Glutamine in the Intestine and Its Implication in Intestinal Diseases

被引：243

作者：

Kim, Min-Hyun ^{[1
]}

Kim, Hyeyoung ^{[2
]}

机构：

[1] Univ Florida, Coll Agr & Life Sci, Ctr Nutr Sci, Food Sci & Human Nutr Dept, Gainesville, FL 32611 USA

[2] Yonsei Univ, Coll Human Ecol, Dept Food & Nutr, Brain Korea PLUS Project 21, Seoul 03722, South Korea

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 05期

关键词：

glutamine; intestinal function; inflammatory bowel disease; short bowel syndrome; nutritional therapy; NF-KAPPA-B; GENOME-WIDE ASSOCIATION; T-LYMPHOCYTE EXPRESSION; INDUCED IL-8 PRODUCTION; SHORT-BOWEL PATIENTS; DOSE GROWTH-HORMONE; TIGHT JUNCTIONS; EPITHELIAL-CELLS; BARRIER FUNCTION; DOUBLE-BLIND;

D O I：

10.3390/ijms18051051

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glutamine, the most abundant free amino acid in the human body, is a major substrate utilized by intestinal cells. The roles of glutamine in intestinal physiology and management of multiple intestinal diseases have been reported. In gut physiology, glutamine promotes enterocyte proliferation, regulates tight junction proteins, suppresses pro-inflammatory signaling pathways, and protects cells against apoptosis and cellular stresses during normal and pathologic conditions. As glutamine stores are depleted during severe metabolic stress including trauma, sepsis, and inflammatory bowel diseases, glutamine supplementation has been examined in patients to improve their clinical outcomes. In this review, we discuss the physiological roles of glutamine for intestinal health and its underlying mechanisms. In addition, we discuss the current evidence for the efficacy of glutamine supplementation in intestinal diseases.

引用

页数：15

共 140 条

[1] Double-blind randomized controlled trial of glutamine-enriched polymeric diet in the treatment of active Crohn's disease
Akobeng, AK
Miller, V
Stanton, J
Elbadri, AM
Thomas, AG
[J]. JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2000, 30 (01) : 78 - 84
[2] Roles of glutamine in neurotransmission
Albrecht, Jan
Sidoryk-Wegrzynowicz, Marta
Zielinska, Magdalena
Aschner, Michael
[J]. NEURON GLIA BIOLOGY, 2010, 6 (04) : 263 - 276
[3] Glutamine: Do the data support the cause for glutamine supplementation in humans?
Alpers, DH
[J]. GASTROENTEROLOGY, 2006, 130 (02) : S106 - S116
[4] Prophylactic effect of dietary glutamine supplementation on interleukin 8 and tumour necrosis factor alpha production in trinitrobenzene sulphonic acid induced colitis
Ameho, CK
Adjei, AA
Harrison, EK
Takeshita, K
Morioka, T
Arakaki, Y
Ito, E
Suzuki, I
Kulkarni, AD
Kawajiri, A
Yamamoto, S
[J]. GUT, 1997, 41 (04) : 487 - 493
[5] Glutamine, as a precursor of glutathione, and oxidative stress
Amores-Sánchez, MI
Medina, MA
[J]. MOLECULAR GENETICS AND METABOLISM, 1999, 67 (02) : 100 - 105
[6] TIGHT JUNCTIONS AND THE MOLECULAR-BASIS FOR REGULATION OF PARACELLULAR PERMEABILITY
ANDERSON, JM
VANITALLIE, CM
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1995, 269 (04): : G467 - G475
[7] Randomised trial of glutamine, selenium, or both, to supplement parenteral nutrition for critically ill patients
Andrews, Peter J. D.
Avenell, Alison
Noble, David W.
Campbell, Marion K.
Croal, Bernard L.
Simpson, William G.
Vale, Luke D.
Battison, Claire G.
Jenkinson, David J.
Cook, Jonathan A.
[J]. BMJ-BRITISH MEDICAL JOURNAL, 2011, 342 : 695
[8] MUSCLE AND PLASMA AMINO-ACIDS FOLLOWING INJURY - INFLUENCE OF INTERCURRENT INFECTION
ASKANAZI, J
CARPENTIER, YA
MICHELSEN, CB
ELWYN, DH
FURST, P
KANTROWITZ, LR
GUMP, FE
KINNEY, JM
[J]. ANNALS OF SURGERY, 1980, 192 (01) : 78 - 85
[9] NF-κB is 25
Baltimore, David
[J]. NATURE IMMUNOLOGY, 2011, 12 (08) : 683 - 685
[10] MAR interacts with occludin and mediates EGF-induced prevention of tight junction disruption by hydrogen peroxide
Basuroy, S
Seth, A
Elias, B
Naren, AP
Rao, R
[J]. BIOCHEMICAL JOURNAL, 2006, 393 : 69 - 77

← 1 2 3 4 5 6 7 8 9 10 →