Endometrial carcinoma first presenting as paraneoplastic cerebellar degeneration

Background. Paraneoplastic degeneration (PCD) is an immune-mediated disorder affecting the cerebellum, characterized by subacute onset of cerebellar dysfunction progressing to severe disability, and is associated with an underlying malignancy. Ovarian carcinoma and breast carcinoma are commonly implicated. Case. We report a rare case PCD in an elderly woman, later diagnosed with endometrial carcinoma. Conclusion. PCD is an unusual and rare manifestation of gynecological malignancies, including endometrial carcinoma, and a high degree of suspicion is required in these cases in order to make the correct diagnosis. (c) 2007 Elsevier Inc. All rights reserved.