Association of MEOX2 polymorphism with nonsyndromic cleft palate only in a Vietnamese population

被引：2

作者：

Tran, Duy L. ^{[1
,4
]}

Imura, Hideto ^{[1
,2
,3
]}

Mori, Akihiro ^{[1
,2
,3
]}

Suzuki, Satoshi ^{[1
,2
,3
]}

Niimi, Teruyuki ^{[1
,2
,3
]}

Ono, Maya ^{[1
,2
,3
]}

Sakuma, Chisato ^{[1
,2
,3
]}

Nakahara, Shinichi ^{[1
]}

Nguyen, Tham T. H. ^{[1
,4
]}

Pham, Phuong T. ^{[4
]}

Viet Hoang ^{[4
]}

Tran, Van T. T. ^{[5
]}

Nguyen, Minh D. ^{[5
]}

Natsume, Nagato ^{[1
,2
,3
]}

机构：

[1] Aichi Gakuin Univ, Div Res & Treatment Oral Maxillofacial Congenital, Nagoya, Aichi, Japan

[2] Aichi Gakuin Dent Hosp, Cleft Lip & Palate Ctr, Nagoya, Aichi, Japan

[3] Aichi Gakuin Dent Hosp, Div Speech Hearing & Language, Nagoya, Aichi, Japan

[4] Nguyen Dinh Chieu Gen Hopsital, Ben Tre, Vietnam

[5] Odonto & Maxillofacial Hosp, Ho Chi Minh, Vietnam

来源：

CONGENITAL ANOMALIES | 2018年 / 58卷 / 04期

基金：

日本学术振兴会;

关键词：

MEOX2; non-syndromic cleft palate; polymorphisms; OROFACIAL CLEFTS; HOMEOBOX GENE; ORAL CLEFTS; ENVIRONMENT INTERACTIONS; CIGARETTE-SMOKING; LIP; MICE; 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN; MUTATIONS; GENOTYPE;

D O I：

10.1111/cga.12259

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

To evaluate the association between the single nucleotide polymorphism (SNP) rs227493 in the MEOX2 gene and nonsyndromic cleft palate only, this research was conducted as a case-control study by comparing a nonsyndromic cleft palate only group with an independent, healthy, and unaffected control group who were both examined by specialists. Based on clinical examination and medical records, we analyzed a total of 570 DNA samples, including 277 cases and 293 controls, which were extracted from dry blood spot samples collected from both the Odonto and Maxillofacial Hospital in Ho Chi Minh City and Nguyen Dinh Chieu Hospital in Ben Tre province, respectively. The standard procedures of genotyping the specific SNP (rs2237493) for MEOX2 were performed on a StepOne Realtime PCR system with TaqMan SNP Genotyping Assays. Significant statistical differences were observed in allelic frequencies (allele T and allele G) between the non-syndromic cleft palate only and control groups in female subjects, with an allelic odds ratio of 1.455 (95% confidence interval: 1.026-2.064) and P<0.05. These study findings suggest that nonsyndromic isolated cleft palate might be influenced by variation of MEOX2, especially SNP rs2237493 in Vietnamese females.

引用

页码：124 / 129

页数：6

共 59 条

[1] World Medical Association Declaration of Helsinki Ethical Principles for Medical Research Involving Human Subjects [J].

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2013, 310 (20) :2191-2194

[2]

Barrett Jeffrey C, 2009, Cold Spring Harb Protoc, V2009, DOI 10.1101/pdb.ip71

[3] Epidemiology, Etiology, and Treatment of Isolated Cleft Palate [J].

Burg, Madeleine L. ;

Chai, Yang ;

Yao, Caroline A. ;

Magee, William, III ;

Figueiredo, Jane C. .

FRONTIERS IN PHYSIOLOGY, 2016, 7

[4] Folic Acid Supplementation Use and the MTHFR C677T Polymorphism in Orofacial Clefts Etiology: An Individual Participant Data Pooled-Analysis [J].

Butali, Azeez ;

Little, Julian ;

Chevrier, Cecile ;

Cordier, Sylvian ;

Steegers-Theunissen, Regine ;

Jugessur, Astanand ;

Oladugba, Bola ;

Mossey, Peter A. .

BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY, 2013, 97 (08) :509-514

[5]

CANDIA AF, 1992, DEVELOPMENT, V116, P1123

[6] Recent advances in craniofacial morphogenesis [J].

Chai, Yang ;

Maxson, Robert E., Jr. .

DEVELOPMENTAL DYNAMICS, 2006, 235 (09) :2353-2375

[7] Basic statistical analysis in genetic case-control studies [J].

Clarke, Geraldine M. ;

Anderson, Carl A. ;

Pettersson, Fredrik H. ;

Cardon, Lon R. ;

Morris, Andrew P. ;

Zondervan, Krina T. .

NATURE PROTOCOLS, 2011, 6 (02) :121-133

[8] THE CHI-2 TEST OF GOODNESS OF FIT [J].

COCHRAN, WG .

ANNALS OF MATHEMATICAL STATISTICS, 1952, 23 (03) :315-345

[9] Mechanisms of MEOX1 and MEOX2 Regulation of the Cyclin Dependent Kinase Inhibitors p21CIP1/WAF1 and p16INK4a in Vascular Endothelial Cells [J].

Douville, Josette M. ;

Cheung, David Y. C. ;

Herbert, Krista L. ;

Moffatt, Teri ;

Wigle, Jeffrey T. .

PLOS ONE, 2011, 6 (12)

[10]

FRASER F C, 1955, Acta Genet Stat Med, V5, P358

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