Diversity of 26-locus Y-STR haplotypes in a Nepalese population sample: Isolation and drift in the Himalayas

被引：39
作者：
Parkin, Emma J.
Kraayenbrink, Thirsa
Opgenort, Jean Robert M. L.
van Driem, George L.
Tuladhar, Nirmal Man
de Knijff, Peter
Jobling, Mark A.
机构：
[1] Univ Leicester, Dept Genet, Leicester LE1 7RH, Leics, England
[2] Leiden Univ, Med Ctr, MGC Dept Human & Clin Genet, Leiden, Netherlands
[3] Leiden Univ, Himalayan Languages Project, Leiden, Netherlands
[4] Tribhuvan Univ, Ctr Nepal & Asian Studies, Kirtipur, Nepal
来源：
FORENSIC SCIENCE INTERNATIONAL | 2007年 / 166卷 / 2-3期
基金：
英国惠康基金;
关键词：
Y chromosome; STRs; microsatellites; haplotype; Nepal; Bhutan; Himalayas;
D O I：
10.1016/j.forsciint.2006.05.007
中图分类号：
DF [法律]; D9 [法律]; R [医药、卫生];
学科分类号：
0301 ; 10 ;
摘要：
Twenty-six Y-chromosomal short tandem repeat (STR) loci were amplified in a sample of 769 unrelated males from Nepal, using two multiplex polymerase chain reaction (PCR) assays. The 26 loci gave a discriminating power of 0.997, with 59% unique haplotypes, and the highest frequency haplotype occurring 12 times. We identified novel alleles at four loci, microvariants at a further two, and nine examples of amelogenin-Y deletions (1.2%). Comparison with a similarly sized Bhutanese sample typed with the same markers suggested histories of isolation and drift, with drift having a greater effect in Bhutan. Extended (11-locus) haplotypes for the Nepalese samples have been submitted to the Y-STR Haplotype Reference Database (YHRD). (c) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：176 / 181
页数：6
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