Homocysteine lowering with folic acid supplements in children: Effects on blood pressure

被引：22
作者：
Papandreou, D. [1 ]
Malindretos, P. [2 ]
Arvanitidou, M. [3 ]
Makedou, A. [1 ]
Rousso, I. [1 ]
机构：
[1] Aristotle Univ Thessaloniki, Dept Pediat 2, Sch Med, Ahepa Gen Hosp, Thessaloniki 54636, Greece
[2] Aristotle Univ Thessaloniki, Dept Pathol, Sch Med, Ahepa Gen Hosp,Renal Unit 1, Thessaloniki 54636, Greece
[3] Aristotle Univ Thessaloniki, Dept Hyg, Sch Med, Ahepa Gen Hosp, Thessaloniki 54636, Greece
来源：
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION | 2010年 / 61卷 / 01期
关键词：
Homocysteine; blood pressure; cardiovascular disease; children; folic acid; TOTAL SERUM HOMOCYSTEINE; SCHOOL-AGE POPULATION; ENDOTHELIAL FUNCTION; PULSE PRESSURE; RENAL-FAILURE; ADOLESCENTS; STIFFNESS; TRIAL;
D O I：
10.3109/09637480903286371
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Hyperhomocysteinemia is emerging as an independent predictor of cardiovascular disease and hypertension among children. The aim of the study was to examine the effects of oral folic acid on homocysteine and blood pressure. Folic acid supplementation has been found to reduce homocysteine levels and in some cases blood pressure. Five hundred and twenty children participated in the study, and 26 of them were found to be hyperhomocysteinemic; 20 of these children randomly received 5 mg oral folic acid supplement while the other six children were the controls. Serum homocysteine (P < 0.001) levels as well as systolic (P < 0.001) and diastolic (P = 0.045) blood pressure were statistically significantly decreased in the intervention group compared with the controls, while folic acid levels were statistically significantly increased (P < 0.001). Total serum homocysteine levels were correlated with age, serum folate, body mass index, and blood pressure. It appears that folic acid may be a safe and effective supplement to reduce homocysteine and possibly blood pressure, which consequently may prevent cardiovascular disease in children in early life.
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页码：11 / 17
页数：7
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