Contemporary development in sequential Knoevenagel, Michael addition multicomponent reaction for the synthesis of 4-Aryl-5-oxo-5H-indeno[1,2-b]pyridine-3-carbonitrile

被引：19
|
作者：
Patravale, Ajinkya A. [1 ]
Gore, Anil H. [1 ]
Patil, Dipti R. [1 ]
Kolekar, Govind B. [1 ]
Deshmukh, Madhukar B. [1 ]
Choudhari, Prafulla B. [2 ]
Bhatia, Manish S. [2 ]
Anbhule, Prashant V. [1 ]
机构：
[1] Shivaji Univ, Dept Chem, Med Chem Res Lab, Kolhapur 416004, MS, India
[2] Bharati Vidyapeeth Coll Pharm, Dept Pharmaceut Chem, Kolhapur 416013, MS, India
来源：
RESEARCH ON CHEMICAL INTERMEDIATES | 2016年 / 42卷 / 04期
关键词：
Sequential multicomponent reaction; Indenopyridine; Domino Knoevenagel-Michael addition; ONE-POT SYNTHESIS; ONE-STEP SYNTHESIS; SOLVENT-FREE; CONVENIENT SYNTHESIS; 3-COMPONENT REACTION; EFFICIENT SYNTHESIS; HANTZSCH REACTION; DOMINO REACTIONS; AQUEOUS-MEDIA; CARBON-CARBON;
D O I：
10.1007/s11164-015-2187-y
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An uncatalyzed efficient synthesis of bioactive pyridine derivatives has been investigated for the first time by a three-component sequential multicomponent reaction tackled with aromatic aldehydes, malononitrile, and 1,3-indandione via Knoevenagel condensation followed by Michael addition. The difference between the domino multicomponent and sequential multicomponent reaction is emphasized by this methodology. The reaction proceeds at ambient temperature without frequently useful N-source like ammonium salt for the construction of N-heterocycles, which makes this protocol a novel synthetic route for the preparation of the indenopyridine skeleton. [GRAPHICS] .
引用
收藏
页码：2919 / 2935
页数：17
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