Formulation techniques for high dose dry powders

被引：46
作者：
Brunaugh, Ashlee D. [1 ]
Smyth, Hugh D. C. [1 ,2 ]
机构：
[1] Univ Texas Austin, Coll Pharm, Div Mol Pharmaceut & Drug Delivery, 2409 West Univ Ave, Austin, TX 78712 USA
[2] Univ Texas Austin, LaMontagne Ctr Infect Dis, Austin, TX 78712 USA
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2018年 / 547卷 / 1-2期
关键词：
Inhalation; Dry powder inhalers; Dry powder formulation; High dose delivery; Carrier-free; Particle engineering; ANTIBIOTIC COMBINATION POWDERS; TOBRAMYCIN INHALATION POWDER; LARGE POROUS PARTICLES; CYSTIC-FIBROSIS; SURFACE-ENERGY; AEROSOL PERFORMANCE; DRUG-DELIVERY; INHALABLE FORMULATIONS; INHALER FORMULATIONS; PULMONARY DELIVERY;
D O I：
10.1016/j.ijpharm.2018.05.036
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Delivery of drugs to the lungs via dry powder inhaler (DPI) is a promising approach for the treatment of both local pulmonary conditions and systemic diseases. Though DPIs are widely used for the pulmonary deposition of potent bronchodilators, anticholinergics, and corticosteroids, there is growing interest in the utilization of this delivery system for the administration of high drug doses to the lungs, as made evident by recent regulatory approvals for anti-microbial, anti-viral and osmotic agents. However, the formulation of high dose DPIs carries several challenges from both a physiological and physicochemical standpoint. This review describes the various formulation techniques utilized to overcome the barriers associated with the pulmonary delivery of high dose powders.
引用
收藏
页码：489 / 498
页数：10
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