Etiopathogenesis of Behcet's disease

被引：132

作者：

Mendoza-Pinto, Claudia ^{[1
]}

Garcia-Carrasco, Mario ^{[1
,2
]}

Jimenez-Hernandez, Mario ^{[1
,7
]}

Jimenez Hernandez, Cesar ^{[1
,7
]}

Riebeling-Navarro, Carlos ^{[3
]}

Nava Zavala, Arnulfo ^{[4
]}

Vera Recabarren, Mauricio ^{[5
]}

Espinosa, Gerard ^{[7
]}

Jara Quezada, Javier ^{[6
]}

Cervera, Ricard ^{[7
]}

机构：

[1] Inst Mexicano Segura Social, HGR 36, Syst Autoimmune Dis Res Unit, Puebla, Mexico

[2] Benemerita Univ Autonoma Puebla, Dept Rheumatol & Immunol, Puebla, Mexico

[3] UMAE Hosp Pediat CMN SXXI, Unidad Epidemiol Invest Clin, Mexico City, DF, Mexico

[4] UMAE IMSS, Unidad Epidemiol Invest Clin, Guadalajara, Jalisco, Mexico

[5] Serv Dermatol Clin Indisa, Santiago, Chile

[6] UMAE, Ctr Med Nacl IMSS, Mexico City, DF, Mexico

[7] Hosp Clin Barcelona, Inst Clin Med & Dermatol, Dept Autoimmune Dis, Barcelona, Catalonia, Spain

来源：

AUTOIMMUNITY REVIEWS | 2010年 / 9卷 / 04期

关键词：

Behcet; Inflammatory; Vasculitis; Etiopathogenesis; SACCHAROMYCES-CEREVISIAE ANTIBODY; VASCULAR INVOLVEMENT; GENE POLYMORPHISMS; T-CELLS; ACTIVATION; ANTIGEN; HLA;

D O I：

10.1016/j.autrev.2009.10.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Bechet's disease (BD) is an inflammatory, multi systemic disease with spontaneous remissions and relapses similar to various autoimmune diseases. BD leads to organ damage, including the eyes. skin, joints, etc., which produces various clinical manifestations. The central histopathologic characteristic is systemic vasculitis with perivascular inflammatory infiltrates. The etiopathogenesis is unknown, although immunological abnormalities, possibly induced by susceptible microbiological pathogens, have been postulated. (C) 2009 Published by Elsevier B.V.

引用

页码：241 / 245

页数：5

共 39 条

[1]

Atagunduz P, 2003, CLIN EXP RHEUMATOL, V21, pS35

[2]

Banks T, 2003, AUST VET PRACT, V33, P40

[3] Involvement of chemokines and Th1 cytokines in the pathogenesis of mucocutaneous lesions of Behqet's disease [J].

Ben Ahmed, M ;

Houman, H ;

Miled, M ;

Dellagi, K ;

Louzir, H .

ARTHRITIS AND RHEUMATISM, 2004, 50 (07) :2291-2295

[4] Epidemiology and Clinical Characteristics of Behcet's Disease in the US: A Population-Based Study [J].

Calamia, Kenneth T. ;

Wilson, Floranne C. ;

Icen, Murat ;

Crowson, Cynthia S. ;

Gabriel, Sherine E. ;

Kremers, Hilal Maradit .

ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH, 2009, 61 (05) :600-604

[5] Anti-Saccharomyces cerevisiae antibody in intestinal Behcet's disease patients:: Relation to clinical course [J].

Choi, Chang Hwan ;

Kim, Tae Il ;

Kim, Byung Chang ;

Shin, Sung Jae ;

Lee, Sang Kil ;

Kim, Won Ho ;

Kim, Hyon Suk .

DISEASES OF THE COLON & RECTUM, 2006, 49 (12) :1849-1859

[6] HLA-B*51 and B*15 alleles confer predisposition to Behcet's disease in Moroccan patients [J].

Choukri, F ;

Chakib, A ;

Himmich, H ;

Hüe, S ;

Caillat-Zucman, S .

HUMAN IMMUNOLOGY, 2001, 62 (02) :180-185

[7] Clinicopathologic evaluation of nodular cutaneous lesions of Behcet syndrome [J].

Demirkesen, C ;

Tüzüner, N ;

Mat, C ;

Senocak, M ;

Büyükbabani, N ;

Tüzün, Y ;

Yazici, H .

AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2001, 116 (03) :341-346

[8]

Eksioglu-Demiralp E, 2001, CLIN EXP RHEUMATOL, V19, pS19

[9] Vascular involvement in Behcet's disease:: Relation with thrombophilic factors, coagulation activation, and thrombomodulin [J].

Espinosa, G ;

Font, J ;

Tàssies, D ;

Vidaller, A ;

Deulofeu, R ;

López-Soto, A ;

Cervera, R ;

Ordinas, A ;

Ingelmo, M ;

Reverter, JC .

AMERICAN JOURNAL OF MEDICINE, 2002, 112 (01) :37-43

[10] Serum leptin concentration is increased in patients with Behcet's syndrome and is correlated with disease activity [J].

Evereklioglu, C ;

Inalöz, HS ;

Kirtak, N ;

Doganay, S ;

Bülbül, M ;

Otlu, B ;

Özerol, E ;

Er, H ;

Özbek, E .

BRITISH JOURNAL OF DERMATOLOGY, 2002, 147 (02) :331-336

← 1 2 3 4 →