Pre-B-Cell Acute Lymphoblastic Leukemia With Bulk Extramedullary Disease and Chromosome 22 (EWSR1) Rearrangement Masquerading as Ewing Sarcoma

被引：13

作者：

Jakovljevic, Gordana ^{[1
]}

Nakic, Melita ^{[1
]}

Rogosic, Srdan ^{[1
]}

Kardum-Skelin, Ika ^{[2
]}

Mrsic-Davidovic, Sanja ^{[3
]}

Zadro, Renata ^{[3
]}

Kruslin, Bozo ^{[4
]}

机构：

[1] Univ Zagreb, Childrens Hosp, Pediat Clin, Dept Hematol & Oncol, Zagreb 10000, Croatia

[2] Univ Zagreb, Merkur Univ Hosp, Clin Internal Med, Lab Cytol & Hematol, Zagreb, Croatia

[3] Univ Zagreb, Clin Hosp, Ctr & Sch Med, Clin Inst Lab Diagnost, Zagreb 41000, Croatia

[4] Univ Zagreb, Sestre Milosrdnice Univ Hosp, Dept Pathol, Zagreb, Croatia

来源：

PEDIATRIC BLOOD & CANCER | 2010年 / 54卷 / 04期

关键词：

Ewing sarcoma family of tumors; EWSRI rearrangement; pre-B-cell lymphoblastic lymphoma/leukemia; t(11; 22)(q24 q12); IMMUNOHISTOCHEMICAL DETECTION; NEUROECTODERMAL TUMOR; GENE; LYMPHOMA; PCR;

D O I：

10.1002/pbc.22365

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report a 2-year-old female with a subcutaneous tumor who was initially misdiagnosed as suffering from Ewing sarcoma with a positive EWSR1 rearrangement and [WS/FL1] transcript. After finding lymphoblasts in peripheral blood, the diagnosis of acute lymphoblastic leukemia was established. This necessitated further analysis of the subcutaneous tumor. The tissue was positive for immature B-cell markers and an immunoglobulin heavy chain gene rearrangement, which confirmed the final diagnosis of common type acute lymphoblastic leukemia with bulk extramedullary disease. The patient was treated with chemotherapy and was in remission 30 months after the diagnosis Pediatr Blood Cancer 2010,54 606 609 (C) 2010 Wiley-Liss, Inc.

引用

页码：606 / 609

页数：4

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