Synthetic α-Helix Mimetics as Agonists and Antagonists of Islet Amyloid Polypeptide Aggregation

被引：98

作者：

Saraogi, Ishu ^{[1
]}

Hebda, James A.

Becerril, Jorge ^{[1
]}

Estroff, Lara A. ^{[1
]}

Miranker, Andrew D. ^{[1
]}

Hamilton, Andrew D. ^{[1
]}

机构：

[1] Yale Univ, Dept Chem, New Haven, CT 06520 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 04期

基金：

美国国家卫生研究院;

关键词：

alpha-helix mimetics; amyloid beta-peptides; diabetes; helical structures; proteomimetics; SMALL-MOLECULE INHIBITORS; FIBRIL FORMATION; TOXICITY; STATES; MECHANISM; CATALYSIS; FOLDAMER; DESIGN;

D O I：

10.1002/anie.200901694

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Figure Presented Split personality: A series of oligoamidebased helix mimetics bind to a complementary helical motif in Islet amyloid polypeptide (IAPP), a protein implicated in the pathology of type II diabetes. These compounds accelerated IAPP amyloid formation under lipid-free conditions, but inhibited it under lipid-catalyzed conditions. hlAPP = human IAPP. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：736 / 739

页数：4

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