Efficient synthesis of 2,3-unsaturated sulfonamidoglycosides by Amberlyst 15

被引：19

作者：

Tempera, Carlos A. ^{[1
]}

Colinas, Pedro A. ^{[1
]}

Bravo, Rodolfo D. ^{[1
]}

机构：

[1] Natl Univ La Plata, LADECOR, Dept Quim, Fac Ciencias Exactas, RA-1900 La Plata, Argentina

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 41期

关键词：

FERRIER REARRANGEMENT; D-GLYCALS; GLYCOSIDES;

D O I：

10.1016/j.tetlet.2010.07.076

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Sulfonamidoglycosylation of D-glycals in the presence of Amberlyst 15 proceeded effectively to afford the sulfonamidoglycosides in good to high yields with minimal workup and short reaction times. Two N-glycosyl sulfonamides were tested as inhibitors of tumor cell growth in vitro and showed antiproliferative properties in the micromolar range. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：5372 / 5374

页数：3

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