One committee to review it all: A single, multi-disciplinary COVID-19 research committee

被引：1

作者：

Migliacci, Jocelyn ^{[1
]}

Rodavitch, Ann ^{[1
]}

Riely, Gregory ^{[1
]}

Sabbatini, Paul ^{[1
]}

Houston, Collette ^{[1
]}

Hanley, Sara ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, New York, NY USA

来源：

CONTEMPORARY CLINICAL TRIALS | 2022年 / 117卷

关键词：

COVID-19; Study start-up; Protocol activation; Protocol review committee; Cancer center support grant (CCSG);

D O I：

10.1016/j.cct.2022.106760

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

On 1/20/2020 when the first case of a novel coronavirus (COVID-19) was confirmed in Washington state, its major impact was unknown. Memorial Sloan Kettering Cancer Center's (MSK) Hospital Incident Command System (HICS) was activated on 2/5, with our first COVID-19 case identified in early March. By 3/17, our Protocol Activation and Human Research Protection Program was fully remote and on 3/23, MSK leadership requested the creation of the COVID-19 Research Committee. Given the race to identify safe and effective treatments for COVID-19, modifications to workflows and review processes were needed. The goal was to provide quick access to COVID-19 treatments to our patients by creating a COVID-19 Committee as a "one-stop" committee, providing comprehensive review of clinical research related to COVID-19 including scientific review mandated by the Cancer Center Support Grant (CCSG) guidelines, prior to IRB review and protocol activation. Protocols that were reviewed by the COVID-19 Committee opened to accrual in an unprecedented 44 days from submission to the committee to open to accrual. Patients were accrued on most of the therapeutic protocols within 1 day of opening. These statistics have prompted our institution to explore how more protocols can benefit from this "one-stop" committee structure.

引用

页数：5