Polar control of the regioselectivity of hetaryne cycloadditions. Synthesis of ellipticine

被引：0

作者：

Diaz, MT

Cobas, A

Guitian, E ^{[1
]}

Castedo, L

机构：

[1] Univ Santiago, CSIC, Dept Quim Organ, Santiago De Compostela 15706, Spain

[2] Univ Santiago, CSIC, Unidad Asociada, Santiago De Compostela 15706, Spain

来源：

SYNLETT | 1998年 / 02期

关键词：

ellipticine; 2-chloro-3,4-didehydropyridine; pyridyne cycloaddition;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A regioselective cycloaddition between 1,3-dimethyl-4-(phenylsulfonyl)-4H-furo[3,4-b]indole and 2-chloro-3,4-didehydropyridine is the key step of a modification of Gribble's approach to ellipticines. The use of a fluoride-promoted elimination for the generation of the pyridyne and the control of the regioselectivity of the cycloaddition improve the yield of ellipticine by a factor of 3.

引用

页码：157 / +

页数：3