Modulating the Blood-Brain Barrier: A Comprehensive Review

被引：41
作者：
Whelan, Rory [1 ,2 ]
Hargaden, Grainne C. [3 ]
Knox, Andrew J. S. [1 ,2 ]
机构：
[1] Tech Univ Dublin, Sch Biol & Hlth Sci, Dublin D07 XT95, Ireland
[2] Technol Univ Dublin, Environm Sustainabil & Hlth Inst, Chem & Struct Biol, Dublin D07 H6K8, Ireland
[3] Technol Univ Dublin, Sch Chem & Pharmaceut Sci, Dublin D07 XT95, Ireland
来源：
PHARMACEUTICS | 2021年 / 13卷 / 11期
关键词：
blood-brain barrier (BBB); CNS drug delivery; tight junction (TJ); BBB permeability; BBB modulation; focused ultrasound; intra-arterial drug delivery; hyperosmolar agents; glioblastoma; alzheimers; GUIDED FOCUSED ULTRASOUND; ZONULA-OCCLUDENS TOXIN; POSITRON-EMISSION-TOMOGRAPHY; ACUTE INFLAMMATORY RESPONSE; TIGHT JUNCTION MODULATION; GLIOMA-BEARING RATS; IN-VITRO; CHEMOTHERAPEUTIC-AGENTS; DRUG-DELIVERY; GENE DELIVERY;
D O I：
10.3390/pharmaceutics13111980
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The highly secure blood-brain barrier (BBB) restricts drug access to the brain, limiting the molecular toolkit for treating central nervous system (CNS) diseases to small, lipophilic drugs. Development of a safe and effective BBB modulator would revolutionise the treatment of CNS diseases and future drug development in the area. Naturally, the field has garnered a great deal of attention, leading to a vast and diverse range of BBB modulators. In this review, we summarise and compare the various classes of BBB modulators developed over the last five decades-their recent advancements, advantages and disadvantages, while providing some insight into their future as BBB modulators.
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页数：54
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