The role of multi-omics in the diagnosis of COVID-19 and the prediction of new therapeutic targets

被引：11

作者：

Ma, Jianli ^{[1
]}

Deng, Yuwei ^{[2
]}

Zhang, Minghui ^{[3
]}

Yu, Jinming ^{[1
]}

机构：

[1] Shandong Univ, Dept Radiat Oncol, Canc Ctr, 440 Jiyan Rd, Jinan 250117, Shandong, Peoples R China

[2] Harbin Med Univ, Canc Hosp, Dept Breast Med Oncol, Harbin, Heilongjiang, Peoples R China

[3] Harbin Med Univ, Canc Hosp, Dept Resp Med Oncol, Harbin 150081, Heilongjiang, Peoples R China

来源：

VIRULENCE | 2022年 / 13卷 / 01期

关键词：

COVID-19; multi-omics; genomics; transcriptomic; proteomics; metabolomics; SARS-COV-2; PATHOGENESIS; TMPRSS2; VIRUS; ACE2;

D O I：

10.1080/21505594.2022.2092941

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus causing COVID-19, has led to more than 170 million confirmed cases in 223 countries and regions, claiming 3,872,457 lives. Some patients with COVID-19 have mild clinical symptoms despite severe respiratory failure, which greatly increases the difficulty of diagnosis and treatment. It is therefore necessary to identify biological characteristics of SARS-CoV-2, screen novel diagnostic and prognostic biomarkers, as well as to explore potential therapeutic targets for COVID-19. In this comprehensive review, we discuss the current published literature on COVID-19. We find that the comprehensive application of genomics, transcriptomics, proteomics and metabolomics is becoming increasingly important in the treatment of COVID-19. Multi-omics analysis platforms are expected to revolutionize the diagnosis and classification of COVID-19. This review aims to provide a reference for diagnosis, surveillance and clinical decision making related to COVID-19.

引用

页码：1101 / 1110

页数：10

共 69 条

[41] Single-cell genomics and spatial transcriptomics: Discovery of novel cell states and cellular interactions in liver physiology and disease biology [J].

Saviano, Antonio ;

Henderson, Neil C. ;

Baumert, Thomas F. .

JOURNAL OF HEPATOLOGY, 2020, 73 (05) :1219-1230

[42] Next-Generation Sequencing of T and B Cell Receptor Repertoires from COVID-19 Patients Showed Signatures Associated with Severity of Disease [J].

Schultheiss, Christoph ;

Paschold, Lisa ;

Simnica, Donjete ;

Mohme, Malte ;

Willscher, Edith ;

von Wenserski, Lisa ;

Scholz, Rebekka ;

Wieters, Imke ;

Dahlke, Christine ;

Tolosa, Eva ;

Sedding, Daniel G. ;

Ciesek, Sandra ;

Addo, Marylyn ;

Binder, Mascha .

IMMUNITY, 2020, 53 (02) :442-+

[43] TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections [J].

Shen, Li Wen ;

Mao, Hui Juan ;

Wu, Yan Ling ;

Tanaka, Yoshimasa ;

Zhang, Wen .

BIOCHIMIE, 2017, 142 :1-10

[44] Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China [J].

Shi, Shaobo ;

Qin, Mu ;

Shen, Bo ;

Cai, Yuli ;

Liu, Tao ;

Yang, Fan ;

Gong, Wei ;

Liu, Xu ;

Liang, Jinjun ;

Zhao, Qinyan ;

Huang, He ;

Yang, Bo ;

Huang, Congxin .

JAMA CARDIOLOGY, 2020, 5 (07) :802-810

[45] Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity [J].

Shin, Donghyuk ;

Mukherjee, Rukmini ;

Grewe, Diana ;

Bojkova, Denisa ;

Baek, Kheewoong ;

Bhattacharya, Anshu ;

Schulz, Laura ;

Widera, Marek ;

Mehdipour, Ahmad Reza ;

Tascher, Georg ;

Geurink, Paul P. ;

Wilhelm, Alexander ;

van der Heden van Noort, Gerbrand J. ;

Ovaa, Huib ;

Mueller, Stefan ;

Knobeloch, Klaus-Peter ;

Rajalingam, Krishnaraj ;

Schulman, Brenda A. ;

Cinatl, Jindrich ;

Hummer, Gerhard ;

Ciesek, Sandra ;

Dikic, Ivan .

NATURE, 2020, 587 (7835) :657-+

[46] Plasma Proteomics Identify Biomarkers and Pathogenesis of COVID-19 [J].

Shu, Ting ;

Ning, Wanshan ;

Wu, Di ;

Xu, Jiqian ;

Han, Qiangqiang ;

Huang, Muhan ;

Zou, Xiaojing ;

Yang, Qingyu ;

Yuan, Yang ;

Bie, Yuanyuan ;

Pan, Shangwen ;

Mu, Jingfang ;

Han, Yang ;

Yang, Xiaobo ;

Zhou, Hong ;

Li, Ruiting ;

Ren, Yujie ;

Chen, Xi ;

Yao, Shanglong ;

Qiu, Yang ;

Zhang, Ding-Yu ;

Xue, Yu ;

Shang, You ;

Zhou, Xi .

IMMUNITY, 2020, 53 (05) :1108-+

[47] Massive and rapid COVID-19 testing is feasible by extraction-free SARS-CoV-2 RT-PCR [J].

Smyrlaki, Ioanna ;

Ekman, Martin ;

Lentini, Antonio ;

de Sousa, Nuno Rufino ;

Papanicolaou, Natali ;

Vondracek, Martin ;

Aarum, Johan ;

Safari, Hamzah ;

Muradrasoli, Shaman ;

Rothfuchs, Antonio Gigliotti ;

Albert, Jan ;

Hoegberg, Bjoern ;

Reinius, Bjoern .

NATURE COMMUNICATIONS, 2020, 11 (01)

[48] Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis [J].

Song, Jin-Wen ;

Lam, Sin Man ;

Fan, Xing ;

Cao, Wen-Jing ;

Wang, Si-Yu ;

Tian, He ;

Chua, Gek Huey ;

Zhang, Chao ;

Meng, Fan-Ping ;

Xu, Zhe ;

Fu, Jun-Liang ;

Huang, Lei ;

Xia, Peng ;

Yang, Tao ;

Zhang, Shaohua ;

Li, Bowen ;

Jiang, Tian-Jun ;

Wang, Raoxu ;

Wang, Zehua ;

Shi, Ming ;

Zhan, Ji-Yuan ;

Wang, Fu-Sheng ;

Shui, Guanghou .

CELL METABOLISM, 2020, 32 (02) :188-+

[49] The 2019-2020 Novel Coronavirus (Severe Acute Respiratory Syndrome Coronavirus 2) Pandemic: A Joint American College of Academic International Medicine-World Academic Council of Emergency Medicine Multidisciplinary COVID-19 Working Group Consensus Paper [J].

Stawicki, Stanislaw P. ;

Jeanmonod, Rebecca ;

Miller, Andrew C. ;

Paladino, Lorenzo ;

Gaieski, David F. ;

Yaffee, Anna Q. ;

De Wulf, Annelies ;

Grover, Joydeep ;

Papadimos, Thomas J. ;

Bloem, Christina ;

Galwankar, Sagar C. ;

Chauhan, Vivek ;

Firstenberg, Michael S. ;

Di Somma, Salvatore ;

Jeanmonod, Donald ;

Garg, Sona M. ;

Tucci, Veronica ;

Anderson, Harry L., III ;

Fatimah, Lateef ;

Worlton, Tamara J. ;

Dubhashi, Siddharth P. ;

Glaze, Krystal S. ;

Sinha, Sagar ;

Opara, Ijeoma Nnodim ;

Yellapu, Vikas ;

Kelkar, Dhanashree ;

El-Menyar, Ayman ;

Krishnan, Vimal ;

Venkataramanaiah, S. ;

Leyfman, Yan ;

Al Thani, Hassan Ali Saoud ;

Nanayakkara, Prabath W. B. ;

Nanda, Sudip ;

Cioe-Pena, Eric ;

Sardesai, Indrani ;

Chandra, Shruti ;

Munasinghe, Aruna ;

Dutta, Vibha ;

Dal Ponte, Silvana Teixeira ;

Izurieta, Ricardo ;

Asensio, Juan A. ;

Garg, Manish .

JOURNAL OF GLOBAL INFECTIOUS DISEASES, 2020, 12 (02) :47-93

[50] The sweet spot: defining virus-sialic acid interactions [J].

Stencel-Baerenwald, Jennifer E. ;

Reiss, Kerstin ;

Reiter, Dirk M. ;

Stehle, Thilo ;

Dermody, Terence S. .

NATURE REVIEWS MICROBIOLOGY, 2014, 12 (11) :739-749

← 1 2 3 4 5 6 7 →