Biosynthesis: Is it time to go retro?

被引：37

作者：

Bachmann, Brian O. ^{[1
,2
]}

机构：

[1] Vanderbilt Univ, Dept Chem, Nashville, TN 37203 USA

[2] Vanderbilt Univ, Vanderbilt Inst Chem Biol, Nashville, TN USA

来源：

NATURE CHEMICAL BIOLOGY | 2010年 / 6卷 / 06期

关键词：

PATHWAYS; ACID;

D O I：

10.1038/nchembio.377

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Artificial biosynthetic pathways are typically assembled and optimized progressively, from earlier to later steps. This commentary highlights the potential of an alternate regressive method for biochemical pathway design and generation, inspired by the retro-evolution hypothesis and the concept of retrosynthesis. In addition to being a pathway design tool, 'bioretrosynthesis' has potential as a construction and optimization methodology.

引用

页码：390 / 393

页数：4

共 18 条

[11]

Marner Wesley D. II, 2009, Biotechnology Journal, V4, P1406, DOI 10.1002/biot.200900167

[12]

Metzenberg RL, 2005, GENETICS, V171, P1445

[13] KEGGconverter: a tool for the in-silico modelling of metabolic networks of the KEGG Pathways database [J].

Moutselos, Konstantinos ;

Kanaris, Ioannis ;

Chatziioannou, Aristotelis ;

Maglogiannis, Ilias ;

Kolisis, Fragiskos N. .

BMC BIOINFORMATICS, 2009, 10 :324

[14] De novo biosynthetic pathways: rational design of microbial chemical factories [J].

Prather, Kristala L. Jones ;

Martin, Collin H. .

CURRENT OPINION IN BIOTECHNOLOGY, 2008, 19 (05) :468-474

[15] Production of the antimalarial drug precursor artemisinic acid in engineered yeast [J].

Ro, DK ;

Paradise, EM ;

Ouellet, M ;

Fisher, KJ ;

Newman, KL ;

Ndungu, JM ;

Ho, KA ;

Eachus, RA ;

Ham, TS ;

Kirby, J ;

Chang, MCY ;

Withers, ST ;

Shiba, Y ;

Sarpong, R ;

Keasling, JD .

NATURE, 2006, 440 (7086) :940-943

[16] Mining and engineering natural-product biosynthetic pathways [J].

Wilkinson, Barrie ;

Micklefield, Jason .

NATURE CHEMICAL BIOLOGY, 2007, 3 (07) :379-386

[17] Optimizing natural products by biosynthetic engineering: Discovery of nonquinone Hsp90 inhibitors [J].

Zhang, Ming-Qiang ;

Gaisser, Sabine ;

Nur-E-Alam, Mohammad ;

Sheehan, Lesley S. ;

Vousden, William A. ;

Gaitatzis, Nikolaos ;

Peck, Gerrard ;

Coates, Nigel J. ;

Moso, Steven J. ;

Radzom, Markus ;

Foster, Teresa A. ;

Sheridan, Rose M. ;

Gregory, Matthew A. ;

Roe, S. Mark ;

Prodromou, Chrisostomos ;

Pearl, Laurence ;

Boyd, Susan M. ;

Wilkinson, Barrie ;

Martin, Christine J. .

JOURNAL OF MEDICINAL CHEMISTRY, 2008, 51 (18) :5494-5497

[18] Engineering natural products using combinatorial biosynthesis and biocatalysis [J].

Zhou, Hui ;

Xie, Xinkai ;

Tang, Yi .

CURRENT OPINION IN BIOTECHNOLOGY, 2008, 19 (06) :590-596

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