Perceived Physical Fatigability Predicts All-Cause Mortality in Older Adults

被引:21
作者
Glynn, Nancy W. [1 ]
Gmelin, Theresa [1 ]
Renner, Sharon W. [2 ]
Qiao, Yujia [1 ]
Boudreau, Robert M. [1 ]
Feitosa, Mary F. [3 ]
Wojczynski, Mary K. [3 ]
Cosentino, Stephanie [4 ]
Andersen, Stacy L. [5 ]
Christensen, Kaare [6 ]
Newman, Anne B. [1 ]
机构
[1] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15261 USA
[2] Columbus State Univ, Dept Kinesiol & Hlth Sci, Columbus, GA USA
[3] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA
[4] Columbia Univ, Dept Neurol, Med Ctr, New York, NY USA
[5] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA
[6] Univ Southern Denmark, Dept Publ Hlth, Unit Epidemiol Biostat & Biodemog, Odense, Denmark
来源
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2022年 / 77卷 / 04期
基金
美国国家卫生研究院;
关键词
Death; Epidemiology; Family study; Fatigue; FATIGUE; LIFE; CAPACITY; HEALTH;
D O I
10.1093/gerona/glab374
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background Perceived physical fatigability is highly prevalent in older adults and associated with mobility decline and other health consequences. We examined the prognostic value of perceived physical fatigability as an independent predictor of risk of death among older adults. Methods Participants (N = 2 906), mean age 73.5 [SD, 10.4] years, 54.2% women, 99.7% white enrolled in the Long Life Family Study, were assessed at Visit 2 (2014-2017) with 2.7 [SD, 1.0] years follow-up. The Pittsburgh Fatigability Scale (PFS), a 10-item, self-administered validated questionnaire (score range 0-50, higher = greater fatigability) measured perceived physical fatigability at Visit 2. Deaths post-Visit 2 through December 31, 2019 were identified by family members notifying field centers, reporting during another family member's annual phone follow-up, an obituary, or Civil Registration System (Denmark). We censored all other participants at their last contact. Cox proportional hazard models predicted mortality by fatigability severity, adjusted for family relatedness and other covariates. Results Age-adjusted PFS Physical scores were higher for those who died (19.1 [SE, 0.8]) compared with alive (12.2, [SE, 0.4]) overall, as well as across age strata (p < .001), except for those 60-69 years (p = .79). Participants with the most severe fatigability (PFS Physical scores >= 25) were over twice as likely to die (hazard ratio, 2.33 [95% CI, 1.65-3.28]) compared with those who had less severe fatigability (PFS Physical scores < 25) after adjustment. Conclusions Our work underscores the utility of the PFS as a novel patient-reported prognostic indicator of phenotypic aging that captures both overt and underlying disease burden that predicts death.
引用
收藏
页码:837 / 841
页数:5
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