Mechanical properties and bioactivity of porous PLGA/TiO2 nanoparticle-filled composites for tissue engineering scaffolds

被引:109
作者
Torres, F. G.
Nazhat, S. N.
Fadzullah, S. H. Sheikh Md
Maquet, V.
Boccaccini, A. R.
机构
[1] Univ London Imperial Coll Sci Technol & Med, Dept Mat, London SW7 2BP, England
[2] Univ London Imperial Coll Sci Technol & Med, Composites Ctr, London SW7 2BP, England
[3] UCL, Eastman Dent Inst, Div Biomat & Tissue Engn, London WC1X 8LD, England
[4] Catholic Univ, Polymers & Composites Grp, Lima, Peru
[5] Univ Liege, Ctr Educ & Res Macromol, B-4000 Cointe Ougree, Belgium
基金
英国工程与自然科学研究理事会;
关键词
particle reinforced composite; mechanical properties; porosity; anisotropy; tissue engineering scaffolds;
D O I
10.1016/j.compscitech.2006.05.018
中图分类号
TB33 [复合材料];
学科分类号
摘要
Poly(lactide-co-glycolide) (PLGA) foams and PLGA/titanium dioxide (TiO(2)) nanoparticle-filled composite foams (porosity > 90%) were produced by thermally induced solid-liquid phase separation (TIPS) and subsequent solvent sublimation. The scaffolds exhibit bimodal and anisotropic pore structures, with tubular macropores (approximately 100 mu m in diameter) interconnected by a network of micropores. Quasi-static compression testing and dynamic mechanical analysis were carried out and the results were correlated to the microstructure observed by SEM, confirming the strong anisotropic behaviour of the foams. A study of the collapse mechanism of the foams porous structure revealed that when compressed in the main pore direction, the scaffolds failure mechanism involves an initial "accommodation" of large regions of the porous structure, followed by the collapse of individual pores in different modes. The bioactivity of the scaffolds was demonstrated by immersion in simulated body fluid (SBF) for up to 28 days. Formation of hydroxyapatite crystals on the scaffold surface was confirmed by X-ray diffraction analysis. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1139 / 1147
页数:9
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