High-frequency and brief-pulse stimulation pulses terminate cortical electrical stimulation-induced afterdischarges

被引：5

作者：

Ren, Zhi-wei ^{[1
]}

Li, Yong-jie ^{[1
]}

Yu, Tao ^{[1
]}

Ni, Duan-yu ^{[1
]}

Zhang, Guo-jun ^{[1
]}

Du, Wei ^{[1
]}

Piao, Yuan-yuan ^{[1
]}

Zhou, Xiao-xia ^{[1
]}

机构：

[1] Capital Med Univ, Xuanwu Hosp, Beijing Inst Funct Neurosurg, Beijing, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2017年 / 12卷 / 06期

关键词：

nerve regeneration; cortical electrical stimulation; afterdischarges; intractable epilepsy; functional brain mapping; high frequency stimulation; low frequency stimulation; neuromodulation; neural regeneration; TEMPORAL-LOBE EPILEPSY; AMYGDALA-KINDLED SEIZURES; PARKINSONS-DISEASE; SURGERY; RATS;

D O I：

10.4103/1673-5374.208576

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Brief-pulse stimulation at 50 Hz has been shown to terminate afterdischarges observed in epilepsy patients. However, the optimal pulse stimulation parameters for terminating cortical electrical stimulation-induced afterdischarges remain unclear. In the present study, we examined the effects of different brief-pulse stimulation frequencies (5, 50 and 100 Hz) on cortical electrical stimulation-induced afterdischarges in 10 patients with refractory epilepsy. Results demonstrated that brief-pulse stimulation could terminate cortical electrical stimulation-induced afterdischarges in refractory epilepsy patients. In conclusion, (1) a brief-pulse stimulation was more effective when the afterdischarge did not extend to the surrounding brain area. (2) A higher brief-pulse stimulation frequency (especially 100 Hz) was more likely to terminate an afterdischarge. (3) A low current intensity of brief-pulse stimulation was more likely to terminate an afterdischarge.

引用

页码：938 / 944

页数：7

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