Biomineralization-Inspired Synthesis of Copper Sulfide-Ferritin Nanocages as Cancer Theranostics

被引：336

作者：

Wang, Zhantong ^{[1
,2
]}

Huang, Peng ^{[3
]}

Jacobson, Orit ^{[4
]}

Wang, Zhe ^{[4
]}

Liu, Yijing ^{[4
]}

Lin, Lisen ^{[4
]}

Lin, Jing ^{[3
]}

Lu, Nan ^{[4
]}

Zhang, Huimin ^{[4
]}

Tian, Rui ^{[1
,2
,4
]}

Niu, Gang ^{[4
]}

Liu, Gang ^{[1
,2
]}

Chen, Xiaoyuan ^{[4
]}

机构：

[1] Xiamen Univ, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen 361102, Peoples R China

[2] Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, Xiamen 361102, Peoples R China

[3] Shenzhen Univ, Sch Med, Dept Biomed Engn, Guangdong Key Lab Biomed Measurements & Ultrasoun, Shenzhen 518060, Peoples R China

[4] NIH, Lab Mol Imaging & Nanomed, Natl Inst Biomed Imaging & Bioengn, Bldg 10, Bethesda, MD 20892 USA

来源：

ACS NANO | 2016年 / 10卷 / 03期

基金：

美国国家卫生研究院; 中国国家自然科学基金;

关键词：

biomimetic synthesis; ferritin; CuS; photoacoustic imaging; PET; photothermal therapy; PHOTOTHERMAL THERAPY; NANOPARTICLES; PROTEIN; NANOMATERIALS; NANOTUBES; SENSORS; BINDING; AGENT; CAGE; DYE;

D O I：

10.1021/acsnano.5b07521

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

It is essential to control the size and morphology of nanoparticles strictly in nanomedicine. Protein cages offer significant potential for templated synthesis of inorganic nanoparticles. In this study, we successfully synthesized ultrasmall copper sulfide (CuS) nanoparticles inside the cavity of ferritin (Fn) nanocages by a biomimetic synthesis method. The uniform CuS Fn nanocages (CuS-Fn NCs) showed strong near-infrared absorbance and high photothennal conversion efficiency. In quantitative ratiometric photoacoustic imaging (PAI), the CuS-Fn NCs exhibited superior photoacoustic tomography improvements for real-time in vivo PAI of entire tumors. With the incorporation of radionuclide Cu-64, (CuS)-Cu-64-Fn NCs also served as an excellent PET imaging agent with higher tumor accumulation compared to free copper. Following the guidance of PAI and PET, CuS Fn NCs were applied in photothermal therapy to achieve superior cancer therapeutic efficiency with good biocompatibility both in vitro and in vivo. The results demonstrate that the bioinspired multifunctional CuS Fn NCs have potential as clinically translatable cancer theranostics and could provide a noninvasive, highly sensitive, and quantitative in vivo guiding method for cancer photothermal therapies in experimental and clinical settings.

引用

页码：3453 / 3460

页数：8

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