One-carbon metabolism in cancer

被引：365

作者：

Newman, Alice C. ^{[1
]}

Maddocks, Oliver D. K. ^{[1
]}

机构：

[1] Univ Glasgow, Inst Canc Sci, Wolfson Wohl Canc Res Ctr, Garscube Estate, Glasgow G61 1QH`, Lanark, Scotland

来源：

BRITISH JOURNAL OF CANCER | 2017年 / 116卷 / 12期

关键词：

cancer metabolism; one-carbon metabolism; serine metabolism; folate cycle; nucleotide synthesis; methylation; SERINE METABOLISM; SYNTHESIS PATHWAY; DNA METHYLATION; GLYCINE; BIOSYNTHESIS; TUMORS; PROLIFERATION; DEHYDROGENASE; URACIL; CELLS;

D O I：

10.1038/bjc.2017.118

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cells require one-carbon units for nucleotide synthesis, methylation and reductive metabolism, and these pathways support the high proliferative rate of cancer cells. As such, anti-folates, drugs that target one-carbon metabolism, have long been used in the treatment of cancer. Amino acids, such as serine are a major one-carbon source, and cancer cells are particularly susceptible to deprivation of one-carbon units by serine restriction or inhibition of de novo serine synthesis. Recent work has also begun to decipher the specific pathways and sub-cellular compartments that are important for one-carbon metabolism in cancer cells. In this review we summarise the historical understanding of one-carbon metabolism in cancer, describe the recent findings regarding the generation and usage of one-carbon units and explore possible future therapeutics that could exploit the dependency of cancer cells on one-carbon metabolism.

引用

收藏

页码：1499 / 1504

页数：6

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