Antioxidant, Antimicrobial, and Insecticidal Properties of a Chemically Characterized Essential Oil from the Leaves of Dittrichia viscosa L.

被引:31
作者
Mssillou, Ibrahim [1 ]
Agour, Abdelkrim [1 ]
Allali, Aimad [2 ]
Saghrouchni, Hamza [3 ]
Bourhia, Mohammed [4 ]
El Moussaoui, Abdelfattah [5 ]
Salamatullah, Ahmad Mohammad [6 ]
Alzahrani, Abdulhakeem [6 ]
Aboul-Soud, Mourad A. M. [7 ]
Giesy, John P. [8 ,9 ,10 ,11 ]
Lyoussi, Badiaa [1 ]
Derwich, Elhoussine [1 ,12 ]
机构
[1] Sidi Mohamed Ben Abdellah Univ, Fac Sci Dhar El Mahraz, Lab Nat Subst Pharmacol Environm Modeling Hlth &, Fes 30000, Morocco
[2] Univ Ibn Tofail ITU, Fac Sci, Lab Plant Anim & AgroInd Prod, Kenitra 14000, Morocco
[3] Cukurova Univ, Inst Nat & Appl Sci, Dept Biotechnol, TR-01330 Adana, Turkey
[4] Univ Hassan 2, Fac Med & Pharm, Lab Chem Biochem Nutr & Environm, Casablanca 20000, Morocco
[5] Sidi Mohammed Ben Abdellah Univ, Fac Sci Dhar El Mahraz, Lab Biotechnol Environm Agrifood & Hlth, Fes 30000, Morocco
[6] King Saud Univ, Coll Food & Agr Sci, Dept Food Sci & Nutr, POB 2460, Riyadh 11451, Saudi Arabia
[7] King Saud Univ, Coll Appl Med Sci, Dept Clin Lab Sci, POB 10219, Riyadh 11433, Saudi Arabia
[8] Univ Saskatchewan, Toxicol Ctr, Saskatoon, SK S7N 5B3, Canada
[9] Univ Saskatchewan, Dept Vet Biomed Sci, Saskatoon, SK S7N 5B4, Canada
[10] Michigan State Univ, Dept Integrat Biol, E Lansing, MI 48824 USA
[11] Baylor Univ, Dept Environm Sci, Waco, TX 76798 USA
[12] Sidi Mohamed Ben Abdellah Univ, Unity GC MS & GC, City Innovat, Fes 30000, Morocco
关键词
antimicrobial; C; maculatus; D; viscosa; free radical; GC-MS; insecticidal characteristic; medicinal plants; volatile compounds; CALLOSOBRUCHUS-MACULATUS; INULA-VISCOSA; MEDICINAL-PLANTS; COLEOPTERA-CHRYSOMELIDAE; STORED CHICKPEA; BORNYL ACETATE; PEST STATUS; EXTRACT; ANTIBACTERIAL; CHINENSIS;
D O I
10.3390/molecules27072282
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Since some synthetic insecticides cause damage to human health, compounds in plants can be viable alternatives to conventional synthetic pesticides. Dittrichia viscosa L. is a perennial Mediterranean plant known to possess biological activities, including insecticidal properties. The chemical composition of an essential oil (EOD) from D. viscosa, as well as its antioxidant, antimicrobial, and insecticidal effects on the cowpea weevil (Callosobruchus maculatus) were determined. Forty-one volatile compounds were identified in EOD, which accounted for 97.5% of its constituents. Bornyl acetate (41%) was a major compound, followed by borneol (9.3%), alpha-amorphene (6.6%), and caryophyllene oxide (5.7%). EOD exhibited significant antioxidant activity in all tests performed, with an IC50 of 1.30 +/- 0.05 mg/mL in the DPPH test and an EC50 equal to 36.0 +/- 2.5 mg/mL in the FRAP assay. In the phosphor-molybdenum test, EOD results ranged from 39.81 +/- 0.7 to 192.1 +/- 0.8 mg AAE/g E. EOD was active on E. coli (9.5 +/- 0.5 mm), S. aureus (31.0 +/- 1.5 mm), C. albicans (20.4 +/- 0.5 mm), and S. cerevisiae (28.0 +/- 1.0 mm), with MICs ranging from 0.1 mg/mL to 3.3 mg/mL. We found that 1 mu L of EOD caused 97.5 +/- 5.0% insect mortality after 96 h in the inhalation test and 60.0 +/- 8.3% in the ingestion assay. The median lethal concentration (LC50) was 7.8 +/- 0.3 mu L EO/L, while the effective concentration in the ingestion test (LC50) was 15.0 +/- 2.1 mu L EO/L. We found that 20 mu L of EOD caused a reduction of more than 91% of C. maculatus laid eggs.
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页数:15
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