LC-MS-guided isolation of 2-(2-phenylethyl)chromone dimers from red soil agarwood of Aquilaria crassna

被引：13

作者：

He, Di ^{[1
]}

Dong, Wen-Hua ^{[1
]}

Li, Wei ^{[1
]}

Yang, Li ^{[1
]}

Yuan, Jing-Zhe ^{[1
]}

Gai, Cui-Juan ^{[1
]}

Cai, Cai-Hong ^{[1
]}

Dai, Hao-Fu ^{[1
]}

Wang, Hao ^{[1
]}

Mei, Wen-Li ^{[1
]}

机构：

[1] Chinese Acad Trop Agr Sci, Hainan Engn Res Ctr Agarwood, Hainan Inst Trop Agr Resources, Inst Trop Biosci & Biotechnol, Haikou 571101, Hainan, Peoples R China

来源：

FITOTERAPIA | 2022年 / 158卷

基金：

中国国家自然科学基金;

关键词：

Red soil agarwood; Aquilaria crassna; 2-(2-phenylethyl)chromone dimers; Cytotoxicity; ARTIFICIAL AGARWOOD; DERIVATIVES; SESQUITERPENOIDS;

D O I：

10.1016/j.fitote.2022.105162

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Six new 2-(2-phenylethyl)chromone dimers (1-6) were isolated from ethyl ether extract of red soil agarwood of Aquilaria crassna from Vietnam by LC-MS-guided fractionation procedure. Their structures were unambiguously elucidated based on HRESIMS, 1D and 2D NMR spectra. The absolute configuration of 2-(2-phenylethypchmmone dimers was determined by comparison of the experimental and computed ECD spectra. Compound 6 displayed cytotoxicity against the human myeloid leukemia cell line (K562) with an IC50 value of 39.49 mu M.

引用

页数：6

共 29 条

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