Extreme self-organization in networks constructed from gene expression data

被引:50
作者
Agrawal, H [1 ]
机构
[1] Weizmann Inst Sci, Dept Phys Complex Syst, IL-76100 Rehovot, Israel
关键词
D O I
10.1103/PhysRevLett.89.268702
中图分类号
O4 [物理学];
学科分类号
0702 ;
摘要
We study networks constructed from gene expression data obtained from many types of cancers. The networks are constructed by connecting vertices that belong to each others' list of K nearest neighbors, with K being an a priori selected non-negative integer. We introduce an order parameter for characterizing the homogeneity of the networks. On minimizing the order parameter with respect to K, degree distribution of the networks shows power-law behavior in the tails with an exponent of unity. Analysis of the eigenvalue spectrum of the networks confirms the presence of the power-law and small-world behavior. We discuss the significance of these findings in the context of evolutionary biological processes.
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页数:4
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