Decoding the Notch signal

被引：52

作者：

Falo-Sanjuan, Julia ^{[1
]}

Bray, Sarah J. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Physiol Dev & Neurosci, Downing St, Cambridge CB2 3DY, England

来源：

DEVELOPMENT GROWTH & DIFFERENTIATION | 2020年 / 62卷 / 01期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

gene regulation; Notch; signalling; transcription; SPLIT COMPLEX GENES; RBP-J; EXPRESSION; BINDING; ENHANCER; PATHWAY; ACTIVATION; CHROMATIN; REPRESSION; SUPPRESSOR;

D O I：

10.1111/dgd.12644

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Notch signalling controls many key cellular processes which differ according to the context where the pathway is deployed due to the transcriptional activation of specific sets of genes. The pathway is unusual in its lack of amplification, also raising the question of how it can efficiently activate transcription with limited amounts of nuclear activity. Here, we focus on mechanisms that enable Notch to produce appropriate transcriptional responses and speculate on models that could explain the current gaps in knowledge.

引用

页码：4 / 14

页数：11

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