Recent development on liquid chromatography-mass spectrometry analysis of oxidized lipids

被引：30
作者：
Li, Luxiao [1 ,2 ]
Zhong, Shanshan [1 ,2 ]
Shen, Xia [1 ,2 ,3 ]
Li, Qiujing [4 ]
Xu, Wenxin [5 ]
Tao, Yongzhen [1 ]
Yin, Huiyong [1 ,2 ,3 ,6 ]
机构：
[1] Chinese Acad Sci, SIBS, Shanghai Inst Nutr & Hlth, CAS Key Lab Nutr Metab & Food Safety, Shanghai 200031, Peoples R China
[2] Chinese Acad Sci, Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China
[4] Zhangzhou Hlth Vocat Coll, Dept Pharm, Zhangzhou 363000, Peoples R China
[5] Zhangzhou Hlth Vocat Coll, Dept Med Technol, Zhangzhou 363000, Peoples R China
[6] Minist Hlth, Key Lab Food Safety Risk Assessment, Beijing 100000, Peoples R China
来源：
FREE RADICAL BIOLOGY AND MEDICINE | 2019年 / 144卷
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
Lipids; Polyunsaturated fatty acids; LC-MS; Lipidomics; Lipid peroxidation; Oxidative stress; PHOSPHOLIPID OXIDATION-PRODUCTS; PRESSURE CHEMICAL-IONIZATION; ION MOBILITY SPECTROMETRY; LOW-DENSITY-LIPOPROTEIN; FREE-RADICAL OXIDATION; IN-VIVO; STRUCTURAL IDENTIFICATION; MITOCHONDRIAL DYSFUNCTION; 4-HYDROXYNONENAL; 4-HNE; CARDIOLIPIN OXIDATION;
D O I：
10.1016/j.freeradbiomed.2019.06.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Polyunsaturated fatty acids (PUFAs) in the cellular membrane can be oxidized by various enzymes or reactive oxygen species (ROS) to form many oxidized lipids. These metabolites are highly bioactive, participating in a variety of physiological and pathophysiological processes. Mass spectrometry (MS), coupled with Liquid Chromatography, has been increasingly recognized as an indispensable tool for the analysis of oxidized lipids due to its excellent sensitivity and selectivity. We will give an update on the understanding of the molecular mechanisms related to generation of various oxidized lipids and recent progress on the development of LC-MS in the detection of these bioactive lipids derived from fatty acids, cholesterol esters, and phospholipids. The purpose of this review is to provide an overview of the formation mechanisms and technological advances in LC-MS for the study of oxidized lipids in human diseases, and to shed new light on the potential of using oxidized lipids as biomarkers and mechanistic clues of pathogenesis related to lipid metabolism. The key technical problems associated with analysis of oxidized lipids and challenges in the field will also discussed.
引用
收藏
页码：16 / 34
页数：19
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