Synthesis of N-aryl 2-chloroacetamides and their chemical reactivity towards various types of nucleophiles

被引：18

作者：

Abdel-Latif, Ehab ^{[1
]}

Fahad, Mustafa M. ^{[1
]}

Ismail, Mohamed A. ^{[1
]}

机构：

[1] Mansoura Univ, Fac Sci, Dept Chem, Mansoura 35516, Egypt

来源：

SYNTHETIC COMMUNICATIONS | 2020年 / 50卷 / 03期

关键词：

2-Chloroacetamides; chloroacetyl chloride; imidazole; sulfides; thiophene; ANTIMICROBIAL ACTIVITY; CHIRAL SWITCH; HETEROCYCLIC SYNTHESIS; BIOLOGICAL EVALUATION; PHASE SYNTHESIS; DERIVATIVES; ANTIBACTERIAL; INHIBITORS; HYBRIDS; DESIGN;

D O I：

10.1080/00397911.2019.1692225

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of various N-aryl 2-chloroacetamides has been described through chloroacetylation of the corresponding aryl amine. The chemical reactivity of N-aryl 2-chloroacetamides is attributed to the easy replacement of its chlorine atom by nucleophiles (namely; oxygen, nitrogen and/or sulfur). Furthermore, this nucleophilic substitution may accompanied by intramolecular cyclization to furnish miscellaneous heterocyclic systems as imidazole, pyrrole, thiazolidine-4-one and thiophene.

引用

页码：289 / 314

页数：26

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