Prenatal caffeine exposure induced high susceptibility to metabolic syndrome in adult female offspring rats and its underlying mechanisms
被引:10
作者:
Pei, Lin-guo
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机构:
Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Nanyang Med Univ, Basic Med Coll, Nanyang 473061, Peoples R ChinaWuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Pei, Lin-guo
[1
,3
]
Yuan, Chao
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h-index: 0
机构:
Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R ChinaWuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Yuan, Chao
[1
]
Guo, Yi-tian
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h-index: 0
机构:
Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R ChinaWuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Guo, Yi-tian
[1
]
Kou, Hao
论文数: 0引用数: 0
h-index: 0
机构:
Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Hubei Prov Key Lab Dev Originated Dis, Wuhan, Peoples R ChinaWuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Kou, Hao
[1
,2
]
Xia, Li-ping
论文数: 0引用数: 0
h-index: 0
机构:
Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Hubei Prov Key Lab Dev Originated Dis, Wuhan, Peoples R ChinaWuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Xia, Li-ping
[1
,2
]
Zhang, Li
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h-index: 0
机构:
Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R ChinaWuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Zhang, Li
[1
]
Yan, You-e
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机构:
Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R ChinaWuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Yan, You-e
[1
]
Xu, Dan
论文数: 0引用数: 0
h-index: 0
机构:
Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Hubei Prov Key Lab Dev Originated Dis, Wuhan, Peoples R ChinaWuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Xu, Dan
[1
,2
]
Wang, Hui
论文数: 0引用数: 0
h-index: 0
机构:
Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Hubei Prov Key Lab Dev Originated Dis, Wuhan, Peoples R ChinaWuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Wang, Hui
[1
,2
]
机构:
[1] Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
[2] Hubei Prov Key Lab Dev Originated Dis, Wuhan, Peoples R China
[3] Nanyang Med Univ, Basic Med Coll, Nanyang 473061, Peoples R China
Our previous studies have demonstrated that prenatal caffeine exposure (PCE) induced an intrauterine programming of hypothalamic-pituitary-adrenal axis (HPAA)-associated neuroendocrine metabolism in 3-month-old offspring rats. In this study, we aimed to confirm this programming disorder and high susceptibility to metabolic syndrome (MS) in 10-month-old female PCE offspring with postnatal catch-up growth. We found that PCE female offspring rats showed decreased bodyweight but a higher rate of weight gain after birth. Moreover, in the offspring, basal hyperinsulinemia and insulin resistance were observed before unpredictable chronic stress (UCS), but serum total cholesterol (TCH) levels and triglyceride/high-density lipoprotein-cholesterol (TG/HDL-C), TCH/HDL-C and low-density lipoprotein-cholesterol/HDL-C (LDL-C/HDL-C) ratio changes were increased after UCS, accompanied by morphological damage of the related tissues. These results suggested that PCE adult female offspring rats were highly susceptible to MS, which is related to HPAA-associated neuroendocrine-metabolic programming disorder. (C) 2017 Elsevier Inc. All rights reserved.
机构:
North Carolina State Univ, Dept Biol Sci, Ctr Human Hlth & Environm, 127 David Clark Labs Campus Box 7617, Raleigh, NC 27695 USANorth Carolina State Univ, Dept Biol Sci, Ctr Human Hlth & Environm, 127 David Clark Labs Campus Box 7617, Raleigh, NC 27695 USA
Jackson, Thomas W.
Ryherd, Garret L.
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h-index: 0
机构:
North Carolina State Univ, Dept Biol Sci, Ctr Human Hlth & Environm, 127 David Clark Labs Campus Box 7617, Raleigh, NC 27695 USANorth Carolina State Univ, Dept Biol Sci, Ctr Human Hlth & Environm, 127 David Clark Labs Campus Box 7617, Raleigh, NC 27695 USA
Ryherd, Garret L.
Scheibly, Chris M.
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h-index: 0
机构:
North Carolina State Univ, Dept Biol Sci, Ctr Human Hlth & Environm, 127 David Clark Labs Campus Box 7617, Raleigh, NC 27695 USANorth Carolina State Univ, Dept Biol Sci, Ctr Human Hlth & Environm, 127 David Clark Labs Campus Box 7617, Raleigh, NC 27695 USA
Scheibly, Chris M.
Sasser, Aubrey L.
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h-index: 0
机构:
North Carolina State Univ, Dept Biol Sci, Ctr Human Hlth & Environm, 127 David Clark Labs Campus Box 7617, Raleigh, NC 27695 USANorth Carolina State Univ, Dept Biol Sci, Ctr Human Hlth & Environm, 127 David Clark Labs Campus Box 7617, Raleigh, NC 27695 USA
Sasser, Aubrey L.
Guillette, T. C.
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h-index: 0
机构:
North Carolina State Univ, Dept Biol Sci, Ctr Human Hlth & Environm, 127 David Clark Labs Campus Box 7617, Raleigh, NC 27695 USANorth Carolina State Univ, Dept Biol Sci, Ctr Human Hlth & Environm, 127 David Clark Labs Campus Box 7617, Raleigh, NC 27695 USA
Guillette, T. C.
Belcher, Scott M.
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h-index: 0
机构:
North Carolina State Univ, Dept Biol Sci, Ctr Human Hlth & Environm, 127 David Clark Labs Campus Box 7617, Raleigh, NC 27695 USANorth Carolina State Univ, Dept Biol Sci, Ctr Human Hlth & Environm, 127 David Clark Labs Campus Box 7617, Raleigh, NC 27695 USA
机构:
Wuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Hubei, Peoples R China
Wuhan Univ, Dept Pediat, Renmin Hosp, Wuhan 430060, Peoples R China
Hubei Prov Key Lab Dev Originated Dis, Wuhan 430071, Peoples R ChinaWuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Hubei, Peoples R China
Xia, Liping
Jiao, Zhexiao
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机构:
Wuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Hubei, Peoples R China
Hubei Prov Key Lab Dev Originated Dis, Wuhan 430071, Peoples R ChinaWuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Hubei, Peoples R China
Jiao, Zhexiao
Pei, Linguo
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h-index: 0
机构:
Wuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Hubei, Peoples R ChinaWuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Hubei, Peoples R China
Pei, Linguo
Yuan, Chao
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Wuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Hubei, Peoples R ChinaWuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Hubei, Peoples R China
Yuan, Chao
Zhao, Yanjuan
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机构:
Wuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Hubei, Peoples R China
Hubei Prov Key Lab Dev Originated Dis, Wuhan 430071, Peoples R ChinaWuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Hubei, Peoples R China
Zhao, Yanjuan
Guo, Yu
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Wuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Hubei, Peoples R China
Hubei Prov Key Lab Dev Originated Dis, Wuhan 430071, Peoples R ChinaWuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Hubei, Peoples R China
Guo, Yu
Wang, Hui
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机构:
Wuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Hubei, Peoples R China
Hubei Prov Key Lab Dev Originated Dis, Wuhan 430071, Peoples R ChinaWuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Hubei, Peoples R China
机构:
Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Wuhan Univ, Zhongnan Hosp, Dept Orthopaed Surg, Wuhan 430071, Peoples R ChinaWuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Wang, Linlong
Shen, Lang
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Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R ChinaWuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Shen, Lang
Ping, Jie
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Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R ChinaWuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Ping, Jie
Zhang, Li
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Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R ChinaWuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Zhang, Li
Liu, Zhongfen
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Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R ChinaWuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Liu, Zhongfen
Wu, Yong
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Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R ChinaWuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Wu, Yong
Liu, Yansong
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Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R ChinaWuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Liu, Yansong
Huang, Hegui
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机构:
Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R ChinaWuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Huang, Hegui
Chen, Liaobin
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h-index: 0
机构:
Wuhan Univ, Zhongnan Hosp, Dept Orthopaed Surg, Wuhan 430071, Peoples R ChinaWuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Chen, Liaobin
Wang, Hui
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h-index: 0
机构:
Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Wuhan Univ, Res Ctr Food & Drug Evaluat, Wuhan 430071, Peoples R ChinaWuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
机构:
North Carolina State Univ, Dept Biol Sci, Ctr Human Hlth & Environm, 127 David Clark Labs Campus Box 7617, Raleigh, NC 27695 USANorth Carolina State Univ, Dept Biol Sci, Ctr Human Hlth & Environm, 127 David Clark Labs Campus Box 7617, Raleigh, NC 27695 USA
Jackson, Thomas W.
Ryherd, Garret L.
论文数: 0引用数: 0
h-index: 0
机构:
North Carolina State Univ, Dept Biol Sci, Ctr Human Hlth & Environm, 127 David Clark Labs Campus Box 7617, Raleigh, NC 27695 USANorth Carolina State Univ, Dept Biol Sci, Ctr Human Hlth & Environm, 127 David Clark Labs Campus Box 7617, Raleigh, NC 27695 USA
Ryherd, Garret L.
Scheibly, Chris M.
论文数: 0引用数: 0
h-index: 0
机构:
North Carolina State Univ, Dept Biol Sci, Ctr Human Hlth & Environm, 127 David Clark Labs Campus Box 7617, Raleigh, NC 27695 USANorth Carolina State Univ, Dept Biol Sci, Ctr Human Hlth & Environm, 127 David Clark Labs Campus Box 7617, Raleigh, NC 27695 USA
Scheibly, Chris M.
Sasser, Aubrey L.
论文数: 0引用数: 0
h-index: 0
机构:
North Carolina State Univ, Dept Biol Sci, Ctr Human Hlth & Environm, 127 David Clark Labs Campus Box 7617, Raleigh, NC 27695 USANorth Carolina State Univ, Dept Biol Sci, Ctr Human Hlth & Environm, 127 David Clark Labs Campus Box 7617, Raleigh, NC 27695 USA
Sasser, Aubrey L.
Guillette, T. C.
论文数: 0引用数: 0
h-index: 0
机构:
North Carolina State Univ, Dept Biol Sci, Ctr Human Hlth & Environm, 127 David Clark Labs Campus Box 7617, Raleigh, NC 27695 USANorth Carolina State Univ, Dept Biol Sci, Ctr Human Hlth & Environm, 127 David Clark Labs Campus Box 7617, Raleigh, NC 27695 USA
Guillette, T. C.
Belcher, Scott M.
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h-index: 0
机构:
North Carolina State Univ, Dept Biol Sci, Ctr Human Hlth & Environm, 127 David Clark Labs Campus Box 7617, Raleigh, NC 27695 USANorth Carolina State Univ, Dept Biol Sci, Ctr Human Hlth & Environm, 127 David Clark Labs Campus Box 7617, Raleigh, NC 27695 USA
机构:
Wuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Hubei, Peoples R China
Wuhan Univ, Dept Pediat, Renmin Hosp, Wuhan 430060, Peoples R China
Hubei Prov Key Lab Dev Originated Dis, Wuhan 430071, Peoples R ChinaWuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Hubei, Peoples R China
Xia, Liping
Jiao, Zhexiao
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h-index: 0
机构:
Wuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Hubei, Peoples R China
Hubei Prov Key Lab Dev Originated Dis, Wuhan 430071, Peoples R ChinaWuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Hubei, Peoples R China
Jiao, Zhexiao
Pei, Linguo
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机构:
Wuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Hubei, Peoples R ChinaWuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Hubei, Peoples R China
Pei, Linguo
Yuan, Chao
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h-index: 0
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Wuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Hubei, Peoples R ChinaWuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Hubei, Peoples R China
Yuan, Chao
Zhao, Yanjuan
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Wuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Hubei, Peoples R China
Hubei Prov Key Lab Dev Originated Dis, Wuhan 430071, Peoples R ChinaWuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Hubei, Peoples R China
Zhao, Yanjuan
Guo, Yu
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Wuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Hubei, Peoples R China
Hubei Prov Key Lab Dev Originated Dis, Wuhan 430071, Peoples R ChinaWuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Hubei, Peoples R China
Guo, Yu
Wang, Hui
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机构:
Wuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Hubei, Peoples R China
Hubei Prov Key Lab Dev Originated Dis, Wuhan 430071, Peoples R ChinaWuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Hubei, Peoples R China
机构:
Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Wuhan Univ, Zhongnan Hosp, Dept Orthopaed Surg, Wuhan 430071, Peoples R ChinaWuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Wang, Linlong
Shen, Lang
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h-index: 0
机构:
Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R ChinaWuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Shen, Lang
Ping, Jie
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h-index: 0
机构:
Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R ChinaWuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Ping, Jie
Zhang, Li
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h-index: 0
机构:
Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R ChinaWuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Zhang, Li
Liu, Zhongfen
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h-index: 0
机构:
Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R ChinaWuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Liu, Zhongfen
Wu, Yong
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h-index: 0
机构:
Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R ChinaWuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Wu, Yong
Liu, Yansong
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h-index: 0
机构:
Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R ChinaWuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Liu, Yansong
Huang, Hegui
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h-index: 0
机构:
Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R ChinaWuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Huang, Hegui
Chen, Liaobin
论文数: 0引用数: 0
h-index: 0
机构:
Wuhan Univ, Zhongnan Hosp, Dept Orthopaed Surg, Wuhan 430071, Peoples R ChinaWuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Chen, Liaobin
Wang, Hui
论文数: 0引用数: 0
h-index: 0
机构:
Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China
Wuhan Univ, Res Ctr Food & Drug Evaluat, Wuhan 430071, Peoples R ChinaWuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China