Neutrophils in cancer, a love-hate affair

被引：14

作者：

Cerezo-Wallis, Daniela ^{[1
]}

Ballesteros, Ivan ^{[1
]}

机构：

[1] Ctr Nacl Invest Cardiovasc Carlos III, Area Cell & Dev Biol, Madrid, Spain

来源：

FEBS JOURNAL | 2022年 / 289卷 / 13期

关键词：

granulopoiesis; immunomodulation; neutrophil heterogeneity; prometastatic neutrophils; tumour stroma; Tumour-associated neutrophils; TUMOR-ASSOCIATED NEUTROPHILS; GR-1+CD11B+ MYELOID CELLS; LYMPHOCYTE RATIO; BONE-MARROW; PROGNOSTIC-FACTOR; SUPPRESSOR-CELLS; PROGENITOR CELLS; METASTASIS; DIFFERENTIATION; POLARIZATION;

D O I：

10.1111/febs.16022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neutrophils dominate the immunological landscape of multiple types of solid tumours in mice and humans and exert different pro- or antitumoral activity. This functional heterogeneity has prompted a search for different subsets and classifications of tumour-infiltrating neutrophils with the idea of better delineating their specific roles in cancer. In this review, we describe current studies that highlight specific mechanisms by which neutrophils exert pro- or antitumoral function and focus on how distinct tumour types induce unique functional states in neutrophils, co-opt granulopoiesis, modulate neutrophil ageing and prolong the neutrophil life span. In addition, we discuss how the tissue-specific tumour stroma and the stage of the cancer influence the function and number of tumour-infiltrating neutrophils. Finally, we explore different approaches to enhance the therapeutic efficacy in cancer types dominated by neutrophils.

引用

页码：3692 / 3703

页数：12

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