Synthesis of β-Hydroxyphosphonate and 1,2-Dihydroxy Acyclic Nucleoside Analogs via 1,3-Dipolar Cycloaddition Strategy

被引：13

作者：

Ganesan, M. ^{[1
]}

Muraleedharan, K. M. ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Madras 600036, Tamil Nadu, India

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2010年 / 29卷 / 02期

关键词：

Nucleoside analogs; triazole spacer; acyclic nucleoside phosphonates; ANTI-HIV ACTIVITY; ANTIVIRAL ACTIVITY; PHOSPHONATES; DERIVATIVES; NUCLEOTIDE; PURINE;

D O I：

10.1080/15257771003597709

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A convenient synthetic approach toward nucleoside analogs where -hydroxyphosphonate- or 1,2-dihydroxy units are connected to the nucleic acid base through a triazole spacer is discussed.

引用

页码：91 / 96

页数：6

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