Evaluation of lauroyl-gemcitabine-loaded hydrogel efficacy in glioblastoma rat models

被引：36

作者：

Bastiancich, Chiara ^{[1
,2
]}

Lemaire, Laurent ^{[2
,3
]}

Bianco, John ^{[1
]}

Franconi, Florence ^{[2
,3
]}

Danhier, Fabienne ^{[1
]}

Preat, Veronique ^{[1
]}

Bastiat, Guillaume ^{[2
]}

Lagarce, Frederic ^{[2
,4
]}

机构：

[1] Catholic Univ Louvain, Adv Drug Delivery & Biomat, Louvain Drug Res Inst, Ave Mounier, B-1200 Brussels, Belgium

[2] UBL, UNIV Angers, Micro & Nanomed Translat MINT, INSERM U1066,CNRS UMR 6021, Angers, France

[3] UBL, PRISM Plateforme Rech Imagerie & Spect Multimoda, PRISM Icat Angers, Angers, France

[4] Angers Univ Hosp, CHU Angers, Pharm Dept, Angers, France

来源：

NANOMEDICINE | 2018年 / 13卷 / 16期

关键词：

glioblastoma; hydrogel; lipid nanocapsules; local delivery; MRI; rat; resection; LIPID NANOCAPSULES; LOCAL CHEMOTHERAPY; GLIADEL WAFERS; BRAIN; RADIOTHERAPY; CARMUSTINE; RESECTION; DRUG; SPECTROSCOPY; TEMOZOLOMIDE;

D O I：

10.2217/nnm-2018-0057

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Anticancer drug-loaded hydrogels are a promising strategy for the local treatment of incurable brain tumors such as glioblastoma (GBM). Recently, we demonstrated the efficacy of lauroyl-gemcitabine lipid nanocapsule hydrogel (GemC(12)-LNC) in a U-87 MG xenograft orthotopic mouse model. In this study, we developed a reliable and reproducible surgical procedure to resect orthotopic GBM tumors in rats. GemC(12)-LNC hydrogel integrity was tested after brain administration in rats and its anti-tumor efficacy was tested on a 9L syngeneic orthotopic model. Results: We demonstrated that LNC integrity is maintained at least for one week after local administration of GemC(12)-LNC. GemC(12)-LNC was able to delay the formation of recurrences in 9L tumor-bearing resected rats, demonstrating the efficacy of this nanomedicine hydrogel in this preclinical model. Conclusion: Our results confirm that GemC(12)-LNC, a hydrogel uniquely formed by a nanocarrier and a cytotoxic drug, could be a promising and safe delivery tool for the local treatment of operable GBM tumors. [GRAPHICS] .

引用

页码：1999 / 2013

页数：15

共 39 条

[1] Delivery of temozolomide to the tumor bed via biodegradable gel matrices in a novel model of intracranial glioma with resection [J].