The propionate of heme binds N4O2 Schiff base antimalarial drug complexes

被引：25

作者：

Ziegler, J ^{[1
]}

Schuerle, T ^{[1
]}

Pasierb, L ^{[1
]}

Kelly, C ^{[1
]}

Elamin, A ^{[1
]}

Cole, KA ^{[1
]}

Wright, DW ^{[1
]}

机构：

[1] Duquesne Univ, Dept Chem & Biochem, Pittsburgh, PA 15282 USA

来源：

INORGANIC CHEMISTRY | 2000年 / 39卷 / 16期

关键词：

D O I：

10.1021/ic000295h

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Schiff base N4O2 complexes offer a flexible template on which to develop novel antimalarial drug complexes that inhibit the aggregation of hemozoin, a detoxification product of the malaria parasite Plasmodium falciparum. The efficacies of these complexes are dependent on the charges of the complexes. Further evidence suggests that these complexes inhibit hemozoin formation via a specific drug/heme propionate salt that prevents the formation of the requisite axial propionato linkage in the repeating dimeric unit of the hemozoin aggregate. [GRAPHICS]

引用

页码：3731 / +

页数：4

共 24 条

[1] ANDERSON J, 1996, MALARIA RES AUDIT IN
[2] FERRIPROTOPORPHYRIN-IX FULFILLS THE CRITERIA FOR IDENTIFICATION AS THE CHLOROQUINE RECEPTOR OF MALARIA PARASITES
CHOU, AC
CHEVLI, R
FITCH, CD
[J]. BIOCHEMISTRY, 1980, 19 (08) : 1543 - 1549
[3] Metalloporphyrins inhibit β-hematin (hemozoin) formation
Cole, KA
Ziegler, J
Evans, CA
Wright, DW
[J]. JOURNAL OF INORGANIC BIOCHEMISTRY, 2000, 78 (02) : 109 - 115
[4] An assessment of drug-haematin binding as a mechanism for inhibition of haematin polymerisation by quinoline antimalarials
Dorn, A
Vippagunta, SR
Matile, H
Jaquet, C
Vennerstrom, JL
Ridley, RG
[J]. BIOCHEMICAL PHARMACOLOGY, 1998, 55 (06) : 727 - 736
[5] Characterisation of synthetic β-haematin and effects of the antimalarial drugs quinidine, halofantrine, desbutylhalofantrine and mefloquine on its formation
Egan, TJ
Hempelmann, E
Mavuso, WW
[J]. JOURNAL OF INORGANIC BIOCHEMISTRY, 1999, 73 (1-2) : 101 - 107
[6] beta-tetraethyl-beta'-tetrapyridin-4-yl porphyrins, their N-methylated tetracations, and heterodimers with ms-tetraphenylsulfonato porphyrins
Endisch, C
Fuhrhop, JH
Buschmann, J
Luger, P
Siggel, U
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (28) : 6671 - 6680
[7] Hemoglobin metabolism in the malaria parasite Plasmodium falciparum
Francis, SE
Sullivan, DJ
Goldberg, DE
[J]. ANNUAL REVIEW OF MICROBIOLOGY, 1997, 51 : 97 - 123
[8] HEMOGLOBIN DEGRADATION IN THE MALARIA PARASITE PLASMODIUM-FALCIPARUM - AN ORDERED PROCESS IN A UNIQUE ORGANELLE
GOLDBERG, DE
SLATER, AFG
CERAMI, A
HENDERSON, GB
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (08) : 2931 - 2935
[9] Probing the chloroquine resistance locus of Plasmodium falciparum with a novel class of multidentate metal(III) coordination complexes
Goldberg, DE
Sharma, V
Oksman, A
Gluzman, IY
Wellems, TE
PiwnicaWorms, D
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (10) : 6567 - 6572
[10] Krogstad Donald J., 1998, P331

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