1D-spectral editing and 2D multispectral in vivo 1H-MRS and 1H-MRSI - Methods and applications

被引:40
作者
Bogner, Wolfgang [1 ]
Hangel, Gilbert [1 ]
Esmaeili, Morteza [2 ,3 ]
Andronesi, Ovidiu C. [3 ]
机构
[1] Med Univ Vienna, Dept Biomed Imaging & Image Guided Therapy, High Field MR Ctr, Vienna, Austria
[2] Norwegian Univ Sci & Technol, Dept Circulat & Med Imaging, NTNU, Trondheim, Norway
[3] Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Martins Ctr Biomed Imaging, Boston, MA 02114 USA
基金
奥地利科学基金会;
关键词
Spectral editing; 2D NMR spectroscopy; Correlation spectroscopy; J-resolved NMR spectroscopy; J-difference editing; Multiple quantum coherence filtering; MAGNETIC-RESONANCE-SPECTROSCOPY; GAMMA-AMINOBUTYRIC-ACID; H-1 MR SPECTROSCOPY; POWER ADIABATIC PULSES; PROTON NMR-SPECTRA; REAL-TIME MOTION; HUMAN-BRAIN; 7; T; OXIDATIVE STRESS; H-1-NMR SPECTRA;
D O I
10.1016/j.ab.2016.12.020
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
This article reviews the methodological aspects of detecting low-abundant J-coupled metabolites via 1D spectral editing techniques and 2D nuclear magnetic resonance (NMR) methods applied in vivo, in humans, with a focus on the brain. A brief explanation of the basics of J-evolution will be followed by an introduction to 1D spectral editing techniques (e.g., J-difference editing, multiple quantum coherence filtering) and 2D-NMR methods (e.g., correlation spectroscopy, J-resolved spectroscopy). Established and recently developed methods will be discussed and the most commonly edited J-coupled metabolites (e.g., neurotransmitters, antioxidants, onto-markers, and markers for metabolic processes) will be briefly summarized along with their most important applications in neuroscience and clinical diagnosis. (C) 2017 The Authors. Published by Elsevier Inc.
引用
收藏
页码:48 / 64
页数:17
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