Enantioselective separation and pharmacokinetic dissipation of cyflumetofen in field soil by ultra-performance convergence chromatography with tandem mass spectrometry

被引:38
作者
Liu, Na [1 ,2 ]
Dong, Fengshou [1 ]
Xu, Jun [1 ]
Liu, Xingang [1 ]
Chen, Zenglong [1 ]
Pan, Xinglu [1 ]
Chen, Xixi [1 ]
Zheng, Yongquan [1 ]
机构
[1] Chinese Acad Agr Sci, Inst Plant Protect, State Key Lab Biol Plant Dis & Insect Pests, Beijing 100193, Peoples R China
[2] Shenyang Agr Univ, Coll Plant Protect, Shenyang 110161, Peoples R China
基金
中国国家自然科学基金;
关键词
Cyflumetofen; Enantioseparation; Enantioselective degradation; Tandem mass spectrometry; Ultra performance convergence chromatography; SUPERCRITICAL-FLUID CHROMATOGRAPHY; CHIRAL PESTICIDES; DEGRADATION; WATER; TEBUCONAZOLE; FRUITS; ENANTIOMERS; ENVIRONMENT; VEGETABLES; ACARICIDE;
D O I
10.1002/jssc.201501123
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Little data on the enantioselective separation of cyflumetofen exists, despite the fact that such data are essential to the assessment of the fate and potential toxic effects of cyflumetofen enantiomers. To address this issue, a simple and sensitive method for the enantioselective determination of cyflumetofen enantiomers in soil has been established using ultra performance convergence chromatography tandem triple quadrupole mass spectrometry. The effects of the chiral stationary phases, mobile phase, auto backpressure regulator pressure, column temperature, flow rate of the mobile phase, and compensation pump solvent were evaluated. The proposed method was applied to the study of the pharmacokinetic dissipation of cyflumetofen stereoisomers in soil under greenhouse conditions. The estimated half-life of cyflumetofen isomers ranged from 12.2 to 13.6 days, and statistically significant enantioselective degradation was observed. This study not only demonstrates that there is an efficient and sensitive method for cyflumetofen enantioseparation, but also provides the first experimental evidence of the pharmacokinetic dissipation of cyflumetofen stereoisomers in the environment.
引用
收藏
页码:1363 / 1370
页数:8
相关论文
共 21 条
[1]   Effect of particle size on the speed and resolution of chiral separations using supercritical fluid chromatography [J].
Biba, Mirlinda ;
Regalado, Erik L. ;
Wu, Naijun ;
Welch, Christopher J. .
JOURNAL OF CHROMATOGRAPHY A, 2014, 1363 :250-256
[2]   Enantiomeric fraction and isomeric composition to assess sources of DDT residues in soils [J].
Bosch, Carme ;
Grimalt, Joan O. ;
Fernandez, Filar .
CHEMOSPHERE, 2015, 138 :40-46
[3]   Systematic and comprehensive strategy for reducing matrix effects in LC/MS/MS analyses [J].
Chambers, Erin ;
Wagrowski-Diehl, Diane M. ;
Lu, Ziling ;
Mazzeo, Jeffrey R. .
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2007, 852 (1-2) :22-34
[4]   Chiral determination of a novel acaricide cyflumetofen enantiomers in cucumber, tomato, and apple by HPLC [J].
Chen, Xiu ;
Dong, Fengshou ;
Liu, Xingang ;
Xu, Jun ;
Li, Jing ;
Li, Yuanbo ;
Li, Minmin ;
Wang, Yunhao ;
Zheng, Yongquan .
JOURNAL OF SEPARATION SCIENCE, 2013, 36 (02) :225-231
[5]   Stereoselective separation and pharmacokinetic dissipation of the chiral neonicotinoid sulfoxaflor in soil by ultraperformance convergence chromatography/tandem mass spectrometry [J].
Chen, Zenglong ;
Dong, Fengshou ;
Xu, Jun ;
Liu, Xingang ;
Cheng, Youpu ;
Liu, Na ;
Tao, Yan ;
Pan, Xinglu ;
Zheng, Yongquan .
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2014, 406 (26) :6677-6690
[6]  
FAO WHO, 2014, 221 FAO WHO, V2014, P61
[7]   Enantiomer fractions are preferred to enantiomer ratios for describing chiral signatures in environmental analysis [J].
Harner, T ;
Wiberg, K ;
Norstrom, R .
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2000, 34 (01) :218-220
[8]  
Hegeman WJM, 2002, REV ENVIRON CONTAM T, V173, P85
[9]   Simultaneous determination of cyflumetofen and its main metabolite residues in samples of plant and animal origin using multi-walled carbon nanotubes in dispersive solid-phase extraction and ultrahigh performance liquid chromatography-tandem mass spectrometry [J].
Li, Minmin ;
Liu, Xingang ;
Dong, Fengshou ;
Xu, Jun ;
Kong, Zhiqiang ;
Li, Yuanbo ;
Zheng, Yongquan .
JOURNAL OF CHROMATOGRAPHY A, 2013, 1300 :95-103
[10]   Determination of cyflumetofen residue in water, soil, and fruits by modified quick, easy, cheap, effective, rugged, and safe method coupled to gas chromatography/tandem mass spectrometry [J].
Li, Minmin ;
Liu, Xingang ;
Dong, Fengshou ;
Xu, Jun ;
Qin, Dongmei ;
Zheng, Yongquan .
JOURNAL OF SEPARATION SCIENCE, 2012, 35 (20) :2743-2749