COVID-19 during pregnancy should we really worry from vertical transmission or rather from fetal hypoxia and placental insufficiency? A systematic review

被引：15

作者：

AbdelMassih, Antoine ^{[1
,2
]}

Fouda, Raghda ^{[3
,4
]}

Essam, Rana ^{[5
]}

Negm, Alhussein ^{[6
]}

Khalil, Dalia ^{[6
]}

Habib, Dalia ^{[7
]}

Afdal, George ^{[6
]}

Ismail, Habiba-Allah ^{[6
]}

Aly, Hadeer ^{[6
]}

Genedy, Ibrahim ^{[6
]}

El Qadi, Layla ^{[6
]}

Makki, Leena ^{[6
]}

Shulqamy, Maha ^{[6
]}

Hanafy, Maram ^{[6
]}

AbdelMassih, Marian ^{[8
]}

Ibrahim, Marina ^{[7
]}

Ebaid, Mohamed ^{[6
]}

Ibrahim, Monica

El-Husseiny, Nadine ^{[9
,10
]}

Ashraf, Nirvana ^{[6
]}

Shebl, Noura ^{[6
]}

Menshawey, Rahma ^{[6
]}

Darwish, Rama ^{[6
]}

ElShahawi, Rana ^{[6
]}

Ramadan, Rana ^{[6
]}

Albala, Sadra ^{[6
]}

Imran, Salwa

Ahmed, Sama ^{[6
]}

Khaldi, Samer ^{[6
]}

Abohashish, Sara ^{[6
]}

Paulo, Stavro ^{[6
]}

Omar, Yasmin ^{[6
]}

Tadros, Mourad Alfy ^{[11
,12
]}

机构：

[1] Cairo Univ, Children Hosp, Fac Med, Pediat Cardiol Unit,Pediat Dept, Kasr Al Ainy St, Cairo 12411, Egypt

[2] Children Canc Hosp Egypt, Pediat Cardiooncol Clin, Cairo, Egypt

[3] Univ Irvine Calif, Irvine, CA USA

[4] Cairo Univ, Clin & Chem Pathol Dept, Fac Med, Cairo, Egypt

[5] Cairo Univ, Fac Med, Pediat Dept, Neonatol Unit, Cairo, Egypt

[6] Cairo Univ, Fac Med, Res Accessibil Team, Student & Internship Res Program, Cairo, Egypt

[7] Cairo Univ, Fac Med, Residents Training Program, Cairo, Egypt

[8] 6th October Univ, Pediat, Cairo, Egypt

[9] Cairo Univ, Fac Dent, Cairo, Egypt

[10] Pixagon Graph Design Agcy, Cairo, Egypt

[11] Mil Med Coll, Cairo, Egypt

[12] Royal Coll Pediat & Child Hlth, London, England

来源：

EGYPTIAN PEDIATRIC ASSOCIATION GAZETTE | 2021年 / 69卷 / 01期

关键词：

COVID-19; Neonatal outcome; Placental infarctions; Fetal hypoxia; Vertical transmission; ACUTE RESPIRATORY SYNDROME; INFECTION; MOTHERS; BORN; SARS;

D O I：

10.1186/s43054-021-00056-0

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Background: COVID-19 is the largest outbreak to strike humanity. The wide scale of fatalities and morbidities lead to a concurrent pandemic of uncertainty in scientific evidence. Conflicting evidences are released on daily basis about the neonatal outcomes of COVID-19-positive mothers. The aim of this study was to use the relevant case reports and series to determine the percentage of newborns who test positive for COVID-19 who are born to COVID-19-positive mothers. Secondary outcomes included examining laboratory abnormalities among COVID-19-positive neonates, and any depicted placental abnormalities in COVID-19-positive mothers. For this purpose, systematic review was performed on all studies reporting primary data on fetus-mother pairs with COVID-19. Data bases were searched for studies that met our inclusion and exclusion criteria. Results: Final screening revealed 67 studies, from which the primary data of 1787 COVID-19 mothers were identified and had their pregnancy outcome analyzed. Only 2.8% of infants born to COVID-19-positive mothers tested positive, and this finding is identical to percentages reported in former Coronaviridae outbreaks, whereas 20% manifested with intrauterine hypoxia alongside placental abnormalities suggestive of heavy placental vaso-occlusive involvement. Conclusions: These findings suggest that while vertical transmission is unlikely, there appears to be an underlying risk of placental insufficiency due to the prothrombotic tendency observed in COVID-19 infection. Guidelines for proper prophylactic anticoagulation in COVID-positive mothers need to be established.

引用

页数：13

共 86 条

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